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  2. Pathophysiology of multiple sclerosis - Wikipedia

    en.wikipedia.org/wiki/Pathophysiology_of...

    In particular, some PPMS patients have been found to have a special genetic variant named rapidly progressive multiple sclerosis [47] which would behave differently from what here is explained. It is due to a mutation inside the gene NR1H3, an arginine to glutamine mutation in the position p.Arg415Gln, in an area that codifies the protein LXRA.

  3. Multiple sclerosis - Wikipedia

    en.wikipedia.org/wiki/Multiple_sclerosis

    Multiple sclerosis (MS) is an autoimmune disease resulting in damage to the insulating covers of nerve cells in the brain and spinal cord. [3] As a demyelinating disease , MS disrupts the nervous system's ability to transmit signals , resulting in a range of signs and symptoms , including physical, mental , and sometimes psychiatric problems.

  4. Signs and symptoms of multiple sclerosis - Wikipedia

    en.wikipedia.org/wiki/Signs_and_symptoms_of...

    Main symptoms of multiple sclerosis Symptoms and findings in multiple sclerosis. Multiple sclerosis can cause a variety of symptoms varying significantly in severity and progression among individuals: changes in sensation (hypoesthesia), muscle weakness, abnormal muscle spasms, or difficulty moving; difficulties with coordination and balance; problems in speech or swallowing (), visual ...

  5. Pathology of multiple sclerosis - Wikipedia

    en.wikipedia.org/.../Pathology_of_multiple_sclerosis

    Abundant extracellular myelin in the meninges of patients with multiple sclerosis has been found [118] Brain tissues with MRI-hidden problems are usually named Normal Appearing. Exploring the normal-appearing corpus callosum has been found a possible primary hypoperfusion, [119] according with other findings in this same direction.

  6. Christina Applegate Details Extent of Brain Damage Caused By MS

    www.aol.com/christina-applegate-details-extent...

    Christina Applegate. Christina Applegate shed new light on her battle with multiple sclerosis (MS).. When it comes to updates, the 52-year-old actress has been on a roll lately, frankly speaking ...

  7. Malignant multiple sclerosis - Wikipedia

    en.wikipedia.org/wiki/Malignant_multiple_sclerosis

    Malignant MS cases are not common, less than 5% of patients with MS experience this type of progression. [ 2 ] The National MS Society Advisory Committee on Clinical Trials of New Agents consensus defined it as: disease with a rapid progressive course, leading to significant disability in multiple neurologic systems or death in a relatively ...

  8. Neuroinflammation - Wikipedia

    en.wikipedia.org/wiki/Neuroinflammation

    In multiple sclerosis, inflammatory cytokines disrupt the blood–brain barrier and allow for the migration of peripheral immune cells into the central nervous system. When they have migrated into the central nervous system , B cells and plasma cells produce antibodies against the myelin sheath that insulates neurons, degrading the myelin and ...

  9. Here's What Happens To Your Brain And Body If You Work ... - AOL

    www.aol.com/news/heres-happens-brain-body-more...

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