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Adapted from Ellis, Frank (2002) Paracetamol: a curriculum resource, Cambridge: Royal Society of Chemistry ISBN: 0-85404-375-6. Author: WhiteTimberwolf, PNG version: Rifleman 82: Permission (Reusing this file)
English: The direct, one-pot synthesis of paracetamol from hydroquinone and ammonium acetate as described in Green Chem., 2014,16, 2997-3002 Date 31 January 2021
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Paracetamol, [a] or acetaminophen, [b] is a non-opioid analgesic and antipyretic agent used to treat fever and mild to moderate pain. [13] [14] [15] It is a widely available over-the-counter drug sold under various brand names, including Tylenol and Panadol. Paracetamol relieves pain in both acute mild migraine and episodic tension headache.
Morse's cited article describes the synthesis of paracetamol from 4-aminophenol and acetic acid. [6] Phenacetin may be synthesized as an example of the Williamson ether synthesis: ethyl iodide, paracetamol, and anhydrous potassium carbonate are heated in 2-butanone to give the crude product, which is recrystallized from water. [7]
An industrial synthesis of paracetamol developed by Hoechst–Celanese involves the conversion of a methyl ketone to an acetanilide via a Beckmann rearrangement. [ 15 ] The thermal rearrangement that occurs in the synthesis of ketamine was claimed to be a Beckmann rearrangement according to: url .
A process flow diagram (PFD) is a diagram commonly used in chemical and process engineering to indicate the general flow of plant processes and equipment. The PFD displays the relationship between major equipment of a plant facility and does not show minor details such as piping details and designations.
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