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Meta-analysis is a method of synthesis of quantitative data from multiple independent studies addressing a common research question. An important part of this method involves computing a combined effect size across all of the studies.
A meta-analysis with some or all studies having more than two arms is called network meta-analysis, indirect meta-analysis, or a multiple treatment comparison. Despite also being an umbrella term, meta-analysis sometimes implies that all included studies have strictly two arms each—same two treatments in all trials—to distinguish itself ...
A meta-analysis is a statistical analysis that combines the results of multiple quantitative studies. Using statistical methods, results are combined to provide evidence from multiple studies. The two types of data generally used for meta-analysis in health research are individual participant data and aggregate data (such as odds ratios or ...
The area of each square is proportional to the study's weight in the meta-analysis. The overall meta-analysed measure of effect is often represented on the plot as a dashed vertical line. This meta-analysed measure of effect is commonly plotted as a diamond, the lateral points of which indicate confidence intervals for this estimate.
The aim of the PRISMA statement is to help authors improve the reporting of systematic reviews and meta-analyses. [3] PRISMA has mainly focused on systematic reviews and meta-analysis of randomized trials, but it can also be used as a basis for reporting reviews of other types of research (e.g., diagnostic studies, observational studies).
In case the origin of heterogeneity can be identified and may be attributed to certain study features, the analysis may be stratified (by considering subgroups of studies, which would then hopefully be more homogeneous), or by extending the analysis to a meta-regression, accounting for (continuous or categorical) moderator variables.
Metascience (also known as meta-research) is the use of scientific methodology to study science itself. Metascience seeks to increase the quality of scientific research while reducing inefficiency.
In the case of a meta-analysis using two-sided tests, it is possible to reject the meta-analysis null hypothesis even when the individual studies show strong effects in differing directions. In this case, we are rejecting the hypothesis that the null hypothesis is true in every study, but this does not imply that there is a uniform alternative ...
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