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Diphenhydramine, sold under the brand name Benadryl among others, is an antihistamine and sedative.It is a first-generation H 1-antihistamine and it works by blocking certain effects of histamine, which produces its antihistamine and sedative effects.
Because of these sedative properties, Benadryl is often used as a sleep aid in people with insomnia. A study published in the American Journal of Geriatric Psychiatry discovered that approximately one in three adults between the ages of 65 and 80 occasionally use over-the-counter drugs like Benadryl to help with sleep. [15]
Sominex is the trademarked name for several over the counter sleep aids.. Different formulations of Sominex are available, depending upon the market. Both the US and UK formulations contain a significant dose of a first generation antihistamine with hypnotic properties.
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Some over-the-counter antihistamines, like Benadryl, contain diphenhydramine, an ingredient that can make people feel sleepy. Doxylamine, an ingredient in some antihistamine and insomnia ...
The toxic dose of Benadryl is quite high. One study of a dog suffering from a toxic dose found that it was probably 111 milligrams per kilogram, or about 100 times the normal dose (3).
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