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Intestinal permeability is a term describing the control of material passing from inside the gastrointestinal tract through the cells lining the gut wall, ...
Zonulin (haptoglobin 2 precursor) [1] is a protein that increases the permeability of tight junctions between cells of the wall of the digestive tract. [2] It was discovered in 2000 by Alessio Fasano and his team at the University of Maryland School of Medicine.
Intestinal permeability is a measurement of intestinal mucosal barrier function and is defined as "the facility with which intestinal epithelium allows molecules to pass through by non-mediated passive diffusion." [11] Permeability in this respect is mostly related to the measurable passage of ions and small inert molecules. Standard methods ...
Since the first publication by Kansy and coworkers, [7] several companies developed their own versions of the assay. Early models incorporated iso-pH conditions in the compartments separated by a simple lipid membrane; subsequently, commercial products were introduced which incorporated more sophisticated lipid membranes. [8]
P-gp is a 170 kDa transmembrane glycoprotein, which includes 10–15 kDa of N-terminal glycosylation.The N-terminal half of the protein contains six transmembrane helixes, followed by a large cytoplasmic domain with an ATP-binding site, and then a second section with six transmembrane helixes and an ATP-binding domain that shows over 65% of amino acid similarity with the first half of the ...
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The normal thickness of the small intestinal wall is 3–5 mm, [6] and 1–5 mm in the large intestine. [7] Focal, irregular and asymmetrical gastrointestinal wall thickening suggests a malignancy. [ 7 ]
We love a roasted vegetable—whether it's a creamy-crisp potato or onion-smothered cauliflower—and we appreciate the convenience of frozen veggies. But it wasn't until recently that we embraced ...
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