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NBIA is not one disease but an entire group of disorders, characterized by an accumulation of brain iron, sometimes in the presence of axonal spheroids in the central nervous system. [3] Iron accumulation can occur anywhere in the brain, with accumulation typically occurring in globus pallidus, substantia nigra, pars reticula, striatum and ...
The specific regions of the brain that are associated with motor functions appear to have larger accumulations of iron than non-motor-related regions. This observation of varying iron concentrations is a possible explanation for the correlation between movement disorders and the iron imbalance within the central nervous system. [3]
Superficial hemosiderosis of the central nervous system is a disease of the brain resulting from chronic iron deposition in neuronal tissues associated with cerebrospinal fluid. This occurs via the deposition of hemosiderin in neuronal tissue, and is associated with neuronal loss, gliosis, and demyelination of neuronal cells.
Mitochondrial membrane protein-associated neurodegeneration (MPAN) is a genetic neurodegenerative disease that causes dystonia, parkinsonism, and iron accumulation in the brain. [ 1 ] [ 2 ] It is caused by mutations to the gene C19orf12 , which has unknown function.
Neuropathology is the study of disease of nervous system tissue, usually in the form of either small surgical biopsies or whole-body autopsies. Neuropathologists usually work in a department of anatomic pathology , but work closely with the clinical disciplines of neurology , and neurosurgery , which often depend on neuropathology for a diagnosis.
Red meat has a high amount of saturated fat and yields an organic compound linked to cardiovascular disease, and the two together may damage the nervous system, which worsens cognitive decline ...
Lead affects every one of the body's organ systems, especially the nervous system, but also the bones and teeth, the kidneys, and the cardiovascular, immune, and reproductive systems. [55] Hearing loss and tooth decay have been linked to lead exposure, [56] as have cataracts. [57] Intrauterine and neonatal lead exposure promote tooth decay.
Pâté flights. Pâté boards. DIY pâté. Pâté, the salty, savory and spreadable food, is having a major moment. People are scooping up the dish, typically made from pureed meat such as chicken ...