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The Randomized Aldactone Evaluation Study (RALES) trial is a landmark clinical study that assessed the impact of spironolactone, an aldosterone antagonist, on morbidity and mortality in patients with severe heart failure due to systolic dysfunction. [1] The findings from this trial significantly influenced the treatment guidelines for heart ...
Spironolactone has been studied in the treatment of rosacea in both males and females. [289] [290] [291] [75] [292] Spironolactone has been studied in fibromyalgia in women. [293] [294] It has also been studied in bulimia nervosa in women, but was not found to be effective. [295]
Spironolactone has been found to be effective in the treatment of hirsutism in women at a dosage of as low as 50 mg/day. [60] At dosages of 100 mg/day and 200 mg/day, observed reductions in hair shaft diameter were 19% ± 8% and 30% ± 3%, respectively ( p = 0.07).
Distal radius fractures are the most common fractures seen in adults and children. [4] Distal radius fractures account for 18% of all adult fractures with an approximate rate of 23.6 to 25.8 per 100,000 per year. [25] For children, both boys and girls have a similar incidence of these types of fractures, however the peak ages differ slightly.
The American Association of People with Disabilities (AAPD) is an American non-profit organization which advocates for the legal rights of people with disabilities, based in Washington, D.C. [1] The mission of AAPD is to increase the political and economic power of people with disabilities.
Like spironolactone, it is a prodrug, and is metabolized to active canrenone in the body. [3] [4] Potassium canrenoate is notable in that it is the only clinically used antimineralocorticoid which is available for parenteral administration (specifically intravenous) [4] [5] as opposed to oral administration. [6]
Unlike spironolactone, bicalutamide has no antimineralocorticoid activity, [97] and for this reason, has no risk of hyperkalemia (which can, rarely/in severe cases, result in hospitalization or death) [112] or other antimineralocorticoid side effects such as urinary frequency, dehydration, hypotension, hyponatremia, metabolic acidosis, or ...
[10] [96] It is an analogue of other spirolactones like spironolactone, canrenone, and spirorenone. [10] [96] Drospirenone differs structurally from spironolactone only in that the C7α acetyl thio substitution of spironolactone has been removed and two methylene groups have been substituted in at the C6β–7β and C15β–16β positions. [97]