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Bronchiolitis obliterans (BO), also known as obliterative bronchiolitis, constrictive bronchiolitis and popcorn lung, is a disease that results in obstruction of the smallest airways of the lungs (bronchioles) due to inflammation. [1] [6] Symptoms include a dry cough, shortness of breath, wheezing and feeling tired. [1]
Popcorn Lung is a debilitating and irreversible respiratory disease which causes "scarring in tiny air sacs in the lungs that lead to excessive coughing and shortness of breath" similar to that ...
The lung disease bronchiolitis obliterans is attributed to prolonged exposure to diacetyl, e.g. in an industrial setting. [2] [3] Workers in several factories that manufacture artificial butter flavoring have been diagnosed with bronchiolitis obliterans, a rare and serious disease of the lungs. [2]
Diacetyl is reported at lower levels in e-cigarettes than in traditional cigarettes. [228] 2, 3-pentanedione is an α-diketone that is chemically and structurally similar to diacetyl. A 2016 report stated that it had become a popular replacement for diacetyl, although it had been shown to cause airway epithelial damage similar to diacetyl. [145]
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Bronchiolitis obliterans, or “popcorn lung,” is a condition where the smallest pathways in the lungs become inflamed, resulting in frequent coughing and shortness of breath.
Diacetyl occurs naturally in alcoholic beverages and some cheeses and is added as a flavoring to some foods to impart its buttery flavor. Chronic inhalation exposure to diacetyl fumes is a causative agent of the lung disease bronchiolitis obliterans, commonly known as "popcorn lung".
U.S. smoking rates have fallen dramatically in the past six decades, from 42.6% of American adults in 1965 to 11.6% in 2022, according to the American Lung Association.