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Giant platelet disorders, also known as macrothrombocytopenia, are rare disorders featuring abnormally large platelets, thrombocytopenia and a tendency to bleeding. Giant platelets cannot stick adequately to injured blood vessel walls, resulting in abnormal bleeding when injured. Giant platelet disorder occurs for inherited diseases like ...
Multisystem inflammatory syndrome in children (MIS-C), or paediatric inflammatory multisystem syndrome (PIMS / PIMS-TS), or systemic inflammatory syndrome in COVID-19 (SISCoV), is a rare systemic illness involving persistent fever and extreme inflammation following exposure to SARS-CoV-2, the virus responsible for COVID-19. [ 7 ]
This is a series of 2 shots given between 12 and 23 months of age. Side Effects can include. soreness at the injection site (1 in 2 adults, 1 in 6 children) headache (1 in 6 adults and 1 in 25 children) loss of appetite (1 in 12 children) tiredness (1 in 14 adults) These problems usually only last 1 or 2 days.
Bernard–Soulier syndrome (BSS) is a rare autosomal recessive bleeding disorder that is caused by a deficiency of the glycoprotein Ib-IX-V complex (GPIb-IX-V), the receptor for von Willebrand factor. [5] The incidence of BSS is estimated to be less than 1 case per million persons, based on cases reported from Europe, North America, and Japan.
Actin-binding proteins have been linked to maintaining the structure of the large platelets. However, enzymatic activity allows for functional clotting activity regardless of the size of the thrombocytes. [7] Genomic studies have found mutations in various pathways that could be the cause of Harris platelet syndrome, but further studies are ...
Thrombocythemia. In hematology, thrombocythemia is a condition of high platelet (thrombocyte) count in the blood. Normal count is in the range of 150 × 10 9 to 450 × 10 9 platelets per liter of blood, [1] but investigation is typically only considered if the upper limit exceeds 750 × 10 9 /L. When the cause is unknown, the term ...
Glanzmann's thrombasthenia is an abnormality of the platelets. [ 2 ] It is an extremely rare coagulopathy (bleeding disorder due to a blood abnormality), in which the platelets contain defective or low levels of glycoprotein IIb/IIIa (GpIIb/IIIa), which is a receptor for fibrinogen. As a result, no fibrinogen bridging of platelets to other ...
Kawasaki disease (also known as mucocutaneous lymph node syndrome) is a syndrome of unknown cause that results in a fever and mainly affects children under 5 years of age. [ 6 ] It is a form of vasculitis, where medium-sized blood vessels become inflamed throughout the body. [ 1 ]