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ALS is a motor neuron disease, which is a group of neurological disordersthat selectively affect motor neurons, the cells that control voluntary musclesof the body.[3] Other motor neuron diseases include primary lateral sclerosis(PLS), progressive muscular atrophy(PMA), progressive bulbar palsy, pseudobulbar palsy, and monomelic amyotrophy(MMA).
Benign fasciculation syndrome (BFS) is characterized by fasciculation (twitching) of voluntary muscles in the body. [1] The twitching can occur in any voluntary muscle group but is most common in the eyelids, arms, hands, fingers, legs, and feet. The tongue can also be affected. The twitching may be occasional to continuous. [2]
A fasciculation, or muscle twitch, is a spontaneous, involuntary muscle contraction and relaxation, involving fine muscle fibers. [1] They are common, with as many as 70% of people experiencing them. [1] They can be benign, or associated with more serious conditions. [1] When no cause or pathology is identified, they are diagnosed as benign ...
Specialty. Neurology, neuromuscular medicine. Neuromyotonia (NMT) is a form of peripheral nerve hyperexcitability that causes spontaneous muscular activity resulting from repetitive motor unit action potentials of peripheral origin. NMT along with Morvan's syndrome are the most severe types in the Peripheral Nerve Hyperexciteability spectrum.
Multifocal motor neuropathy (MMN) is a progressively worsening condition where muscles in the extremities gradually weaken. The disorder, a pure motor neuropathy syndrome, is sometimes mistaken for amyotrophic lateral sclerosis (ALS) because of the similarity in the clinical picture, especially if muscle fasciculations are present.
Cramp fasciculation syndrome (CFS) is a rare [1] peripheral nerve hyperexcitability disorder. It is more severe than the related (and common) disorder known as benign fasciculation syndrome ; it causes fasciculations , cramps, pain, fatigue, and muscle stiffness similar to those seen in neuromyotonia (another related condition). [ 2 ]
Clonus is a sign of certain neurological conditions, particularly associated with upper motor neuron lesions involving descending motor pathways, and in many cases is accompanied by spasticity (another form of hyperexcitability). [1] Unlike small spontaneous twitches known as fasciculations (usually caused by lower motor neuron pathology ...
There are more than 25 genes known to be associated with amyotrophic lateral sclerosis (ALS) as of June 2018, [ 1 ] which collectively account for about 70% of cases of familial ALS (fALS) and 10% of cases of sporadic ALS (sALS). [ 2 ] About 5–10% of cases of ALS are directly inherited. [ 3 ] Overall, first-degree relatives of an individual ...