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About 14% of an oral dosage is converted to this metabolite, which is long-acting (6 to 8 hr) and a noncompetitive antagonist at the AT 1 receptor, contributing to the pharmacological effects of losartan. EXP3174 is 10-40 times more potent in blocking AT 1 receptors than losartan. In addition, the binding to the target enzyme is pH-sensitive ...
Candesartan has a very low maintenance dose. Like olmesartan, the metabolism of the drug is unusual as it is a cascading prodrug. Candesartan has good bioavailibilityand is the most potent by weight of the AT-1 receptorantagonists. It was patented in 1990 and approved for medical use in 1997. [2] Medical uses.
DTXSID80166052. Losartan/hydrochlorothiazide, sold under the brand name Hyzaar among others, is a fixed-dose combination medication used to treat high blood pressure when losartan is not sufficient. [1][2] It consists of losartan, an angiotensin II receptor blocker; and hydrochlorothiazide, a thiazide diuretic. [1][2] It is taken by mouth. [1][2]
Some of the most common reasons to change antidepressants include: Side effects. Many antidepressants can cause side effects, including nausea, digestive issues, headaches and difficulty sleeping ...
Antihypertensive. Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). [ 1 ] Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke, heart failure, kidney failure and myocardial infarction. Evidence suggests that reduction of the blood pressure by 5 mmHg ...
Metoprolol is a beta blocker, or an antagonist of the β-adrenergic receptors. It is specifically a selective antagonist of the β 1 -adrenergic receptor and has no intrinsic sympathomimetic activity. [37] Metoprolol exerts its effects by blocking the action of certain neurotransmitters, specifically adrenaline and noradrenaline.
Clonazepam is prescribed for short-term management of epilepsy, anxiety, obsessive–compulsive disorder(OCD), and panic disorderwith or without agoraphobia. [22][23][24] Seizures. [edit] Clonazepam, like other benzodiazepines, while being a first-line treatment for acute seizures, is not suitable for the long-term treatment of seizures due to ...
Sertraline, sold under the brand name Zoloft among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. [ 10 ] The effectiveness of sertraline for depression is similar to that of other antidepressants, and the differences are mostly confined to side effects. Sertraline is better tolerated than the older ...