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The depot forms are not suitable for initial treatment, but are suitable for patients who have demonstrated inconsistency with oral dosages. [ citation needed ] The decanoate ester of haloperidol ( haloperidol decanoate , trade names Haldol decanoate, Halomonth, Neoperidole) has a much longer duration of action , so is often used in people ...
Haloperidol decanoate is provided in the form of 50 or 100 mg/mL oil solution of sesame oil and benzyl alcohol in ampoules or pre-filled syringes. [6] [7] [9] Its elimination half-life after multiple doses is 21 days. [10] [11] The medication is marketed in many countries throughout the world. [3] [12
A depot injection is a term for an injection formulation of a medication which releases slowly over time to permit less frequent administration of a medication. They are designed to increase medication adherence and consistency, especially in patients who commonly forget to take their medicine. Depot injections can be created by modifying the ...
Typical antipsychotic. Typical antipsychotics (also known as major tranquilizers, and first generation antipsychotics) are a class of antipsychotic drugs first developed in the 1950s and used to treat psychosis (in particular, schizophrenia). Typical antipsychotics may also be used for the treatment of acute mania, agitation, and other conditions.
Antipsychotics in long-acting injectable (LAI), or "depot", form have been suggested as a method of decreasing medication nonadherence (sometimes also called non-compliance). [3] [41] NICE advises LAIs be offered to patients when preventing covert, intentional nonadherence is a clinical priority. [42]
Depot injections are usually either oil-based or an aqueous suspension. Depot injections may be available as certain salt forms of a drug, such as decanoate salts or esters. Examples of depot injections include haloperidol decanoate , medroxyprogesterone acetate , [ 26 ] and naltrexone .
Zuclopenthixol is available in three major preparations: . As zuclopenthixol decanoate (Clopixol Depot, Cisordinol Depot), it is a long-acting intramuscular injection.Its main use is as a long-acting injection given every two or three weeks to people with schizophrenia who have a poor compliance with medication and suffer frequent relapses of illness. [7]
Haloperidol decanoate, an antipsychotic ester. An antipsychotic ester is an ester of an antipsychotic . [ 1 ] They are used clinically as prodrugs to increase fat solubility and thereby prolong duration when antipsychotics are used as depot injectables .