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This is a list of chemotherapeutic agents, also known as cytotoxic agents or cytostatic drugs, that are known to be of use in chemotherapy for cancer.This list is organized by type of agent, although the subsections are not necessarily definitive and are subject to revision.
Osteoporosis, including drug- and cancer-related osteoporosis, giant cell tumour of bone and hypercalcaemia of malignancies: Hypercholesterolaemia, cataract, urinary retention, hypocalcaemia, osteonecrosis of the jaw and anaphylaxis. Gemtuzumab ozogamicin: IV: CD33 antibody that induces apoptosis of the tagged cell. Acute myeloid leukaemia
The original edition, known as the Toxic Substances List was published on June 28, 1971, and included toxicological data for approximately 5,000 chemicals. The name changed later to its current name Registry of Toxic Effects of Chemical Substances. In January 2001 the database contained 152,970 chemicals.
Researchers can either look for cytotoxic compounds, if they are interested in developing a therapeutic that targets rapidly dividing cancer cells, for instance; or they can screen "hits" from initial high-throughput drug screens for unwanted cytotoxic effects before investing in their development as a pharmaceutical. [3]
It has been determined that current personal protective equipment (PPE) does not provide adequate protection against workers handling hazardous drugs - NIOSH states that “... measurable concentrations of some hazardous drugs have been documented in the urine of health care workers who prepared or administered them − even after safety ...
The NIOSH definition is the only definition that includes drug vapors. [8] NIOSH considers the containment of vapor extremely important, such that in September 2015, NIOSH issued a Testing Protocol to assess the effectiveness of closed systems. [9] NIOSH developed and tested five CSTDs to assess its "closeness". Two of the five CSTDs tested passed.
Description of the list of classifications Archived 2013-07-28 at the Wayback Machine, IARC. List of Classifications (latest version) List of Classifications by cancer sites with sufficient or limited evidence in humans, Volumes 1 to 124 (Last update: 8 July 2019) Agents Classified by the IARC Monographs, Volumes 1–123 (Last update: 25 March ...
Other drugs used to treat myeloma such as lenalidomide have shown promise in treating AL amyloidosis. [173] Chemotherapy drugs are also used in conditioning regimens prior to bone marrow transplant (hematopoietic stem cell transplant). Conditioning regimens are used to suppress the recipient's immune system in order to allow a transplant to ...