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Intercalated discs or lines of Eberth are microscopic identifying features of cardiac muscle. Cardiac muscle consists of individual heart muscle cells (cardiomyocytes) connected by intercalated discs to work as a single functional syncytium. By contrast, skeletal muscle consists of multinucleated muscle fibers and exhibits no intercalated discs ...
Gap Junctions have been observed in various animal organs and tissues where cells contact each other. From the 1950s to 1970s they were detected in: Human islet of Langerhans, [44] myometrium, [45] and eye lens [46] Rat pancreas, liver, adrenal cortex, epididymis, duodenum, muscle, [47] and seminiferous tubules [48] Rabbit cornea, [49] ovary ...
Intercalated disc architecture was severely impaired and connexin 43-resident gap junctions were markedly reduced. Electrocardiogram measurements captured spontaneous lethal ventricular arrhythmias in the double transgenic animals, suggesting that the two catenins—β-catenin and plakoglobin—are critical and indispensable for ...
Anatomical terminology. [edit on Wikidata] The spinal cord is a long, thin, tubular structure made up of nervous tissue that extends from the medulla oblongata in the lower brainstem to the lumbar region of the vertebral column (backbone) of vertebrate animals. The center of the spinal cord is hollow and contains a structure called the central ...
A muscle cell, also known as a myocyte, is a mature contractile cell in the muscle of an animal. [1] In humans and other vertebrates there are three types: skeletal, smooth, and cardiac (cardiomyocytes). [2] A skeletal muscle cell is long and threadlike with many nuclei and is called a muscle fiber. [3] Muscle cells develop from embryonic ...
Intervertebral disc. An intervertebral disc (or intervertebral fibrocartilage) lies between adjacent vertebrae in the vertebral column. Each disc forms a fibrocartilaginous joint (a symphysis), to allow slight movement of the vertebrae, to act as a ligament to hold the vertebrae together, and to function as a shock absorber for the spine.
DSC2. Desmocollin-2 is a protein that in humans is encoded by the DSC2 gene. [5][6] Desmocollin-2 is a cadherin -type protein that functions to link adjacent cells together in specialized regions known as desmosomes. Desmocollin-2 is widely expressed, and is the only desmocollin isoform expressed in cardiac muscle, where it localizes to ...
In cardiac muscle, Cadherin-2 is an integral component in adherens junctions residing at intercalated discs, which function to mechanically and electrically couple adjacent cardiomyocytes. Alterations in expression and integrity of Cadherin-2 has been observed in various forms of disease, including human dilated cardiomyopathy .