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  2. Luspatercept - Wikipedia

    en.wikipedia.org/wiki/Luspatercept

    Luspatercept, sold under the brand name Reblozyl, is a medication used for the treatment of anemia in beta thalassemia and myelodysplastic syndromes. [ 5 ] The US Food and Drug Administration (FDA) considers it to be a first-in-class medication .

  3. Myelodysplastic syndrome - Wikipedia

    en.wikipedia.org/wiki/Myelodysplastic_syndrome

    Luspatercept is a TGFβ ligand that acts to decrease SMAD2 and SMAD3 signaling involved in erythropoeisis and may be used in MDS with anemia that is not responsive to erythrocyte stimulating agents or mild MDS with ring sideroblasts. Luspatercept was shown to decrease the need for transfusions and this effect lasted for a median of 30.6 weeks.

  4. Darbepoetin alfa - Wikipedia

    en.wikipedia.org/wiki/Darbepoetin_alfa

    Darbepoetin alfa / d ɑːr b ə ˈ p oʊ ɪ t ɪ n / is a re-engineered form of erythropoietin containing 5 amino acid changes (N30, T32, V87, N88, T90) resulting in the creation of 2 new sites for N-linked carbohydrate addition.

  5. Mycophenolic acid - Wikipedia

    en.wikipedia.org/wiki/Mycophenolic_acid

    Mycophenolic acid is an immunosuppressant medication used to prevent rejection following organ transplantation and to treat autoimmune conditions such as Crohn's disease and lupus.

  6. Asunercept - Wikipedia

    en.wikipedia.org/wiki/Asunercept

    Asunercept blocks the CD95–ligand from binding to the CD95-receptor (CD95), which induces apoptosis.In oncology, this blockade is intended to prevent the killing of activated T cells [7] that can be induced by tumor-associated macrophages (TAMs), [8] endothelial cells, [9] or fibroblasts.

  7. Rucaparib - Wikipedia

    en.wikipedia.org/wiki/Rucaparib

    Rucaparib, sold under the brand name Rubraca, is a PARP inhibitor used as an anti-cancer agent. [2] Rucaparib is a first-in-class pharmaceutical drug targeting the DNA repair enzyme poly-ADP ribose polymerase-1 (PARP-1).

  8. Lipoglycopeptide - Wikipedia

    en.wikipedia.org/wiki/Lipoglycopeptide

    Lipoglycopeptides are a class of antibiotic that have lipophilic side-chains linked to glycopeptides.The class includes oritavancin, telavancin and dalbavancin. [1] [2]In September 2009 the US Food and Drug Administration (FDA) approved telavancin (Vibativ) for complicated skin and skin structure infections (cSSSI) On May 23, 2014, the FDA approved dalbavancin (Dalvance), an injectable drug ...

  9. Netupitant - Wikipedia

    en.wikipedia.org/wiki/Netupitant

    Netupitant is a selective NK 1 receptor antagonist. [6]Netupitant is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity. Netupitant competitively binds to and blocks the activity of the human substance P/NK1 receptors in the central nervous system (CNS), thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which ...