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Somatostatin, also known as growth hormone-inhibiting hormone (GHIH) or by several other names, is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones.
In both species, the peptide hormone Urocortin III (Ucn3) is a major local signal that is released from beta cells (and alpha cells in primates) to induce the local secretion of somatostatin. [3] It has also been suggested that somatostatin may be implicated in insulin-induced hypoglycaemia through a mechanism involving SGLT-2 receptors.
Somatostatin is encoded by a CRE and is very susceptible to gene promoter region activation by transcription factor CREB. [1] There are five known somatostatin receptors: [2] SST 1 ; SST 2 ; SST 3 ; SST 4 ; SST 5 ; All are G protein-coupled seven transmembrane receptors.
20607 Ensembl ENSG00000278195 ENSMUSG00000044933 UniProt P32745 P30935 RefSeq (mRNA) NM_001051 NM_001278687 NM_009218 NM_001356961 RefSeq (protein) NP_001042 NP_001265616 NP_033244 NP_001343890 Location (UCSC) Chr 22: 37.2 – 37.21 Mb Chr 15: 78.42 – 78.43 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Shekel Somatostatin receptor type 3 is a protein that in humans is encoded by ...
The somatostatin hormone itself can negatively affect the uptake of hormones in the body and may play a role in some hormonal conditions. Somatostatin 2 receptors have been found in concentration on the surface of tumor cells, particularly those associated with the neuroendocrine system where the overexpression of somatostatin can lead to many complications [22] [23] Due to this, these ...
Somatostatin family; Motilin family; Substance P. Ghrelin is a peptide hormone released from the stomach and liver and is often referred to as the "hunger hormone" since high levels of it are found in individuals that are fasting. Ghrelin agonistic treatments can be used to treat illnesses such as anorexia and loss of appetites in cancer patients.
The 99m Tc product is supplied as a kit with two vials, one containing the chelating agent ethylenediaminediacetic acid (EDDA) and the other the HYNIC-Tyr3-octreotide chelator and somatostatin analog. [13] Approximately 400-700 MBq may be administered, with imaging at 2, 4, and occasionally 24 hours post administration.
Somatostatin receptor type 5 is a protein that in humans is encoded by the SSTR5 gene. [5] Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner.