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  2. Telomerase - Wikipedia

    en.wikipedia.org/wiki/Telomerase

    If a drug can inhibit telomerase in cancer cells, the telomeres of successive generations will progressively shorten, limiting tumor growth. [56] Telomerase is a good biomarker for cancer detection because most human cancer cells express high levels of it. Telomerase activity can be identified by its catalytic protein domain .

  3. Telomeres in the cell cycle - Wikipedia

    en.wikipedia.org/wiki/Telomeres_in_the_cell_cycle

    Two concerns with applying telomerase inhibitors in cancer treatment are that effective treatment requires continuous, long-term drug application and that off-target effects are common. [30] For example, the telomerase inhibitor imetelstat, first proposed in 2003, [31] [32] has been held up in clinical trials due to hematological toxicity. [30]

  4. Telomerase reverse transcriptase - Wikipedia

    en.wikipedia.org/wiki/Telomerase_reverse...

    90% of cancers are characterized by increased telomerase activity. [28] Lung cancer is the most well characterized type of cancer associated with telomerase. [29] There is a lack of substantial telomerase activity in some cell types such as primary human fibroblasts, which become senescent after about 30–50 population doublings. [28]

  5. Relationship between telomeres and longevity - Wikipedia

    en.wikipedia.org/wiki/Relationship_between...

    In most multicellular eukaryotic organisms, telomerase is active only in germ cells, some types of stem cells such as embryonic stem cells, and certain white blood cells. [9] Telomerase can be reactivated and telomeres restored to the embryonic state by somatic cell nuclear transfer. [18]

  6. Alternative Lengthening of Telomeres - Wikipedia

    en.wikipedia.org/wiki/Alternative_lengthening_of...

    Alternative Lengthening of Telomeres (also known as "ALT") is a telomerase-independent mechanism by which cancer cells avoid the degradation of telomeres.. At each end of the chromosomes of most eukaryotic cells, there is a telomere: a region of repetitive nucleotide sequences which protects the end of the chromosome from deterioration or from fusion with neighboring chromosomes.

  7. Cancer biomarker - Wikipedia

    en.wikipedia.org/wiki/Cancer_biomarker

    Levels or presence of biomarker should readily distinguish between normal, cancerous, and precancerous tissue; Effective treatment of the cancer should change the level of the biomarker; Level of the biomarker should not change spontaneously or in response to other factors not related to the successful treatment of the cancer

  8. Tumor marker - Wikipedia

    en.wikipedia.org/wiki/Tumor_marker

    Tumor markers can be molecules that are produced in higher amounts by cancer cells than normal cells, but can also be produced by other cells from a reaction with the cancer. [ 2 ] The markers can't be used to give patients a diagnosis but can be compared with the result of other tests like biopsy or imaging.

  9. Telomere - Wikipedia

    en.wikipedia.org/wiki/Telomere

    Human chromosomes (grey) capped by telomeres (white). A telomere (/ ˈ t ɛ l ə m ɪər, ˈ t iː l ə-/; from Ancient Greek τέλος (télos) 'end' and μέρος (méros) 'part') is a region of repetitive nucleotide sequences associated with specialized proteins at the ends of linear chromosomes (see Sequences).

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