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Amyloid-related imaging abnormalities (ARIA) are abnormal differences seen in magnetic resonance imaging of the brain in patients with Alzheimer's disease. ARIA is associated with anti-amyloid drugs, particularly human monoclonal antibodies such as aducanumab. [1] There are two types of ARIA: ARIA-E and ARIA-H.
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Illustration of how Alzheimer’s Disease spreads through the brain Credit: National Institute on Aging, National Institutes of Health: Date: 17 November 2008, 13:32: Source: Alzheimer’s Disease, Spreads through the Brain: Author: NIH Image Gallery from Bethesda, Maryland, USA: Other versions
Subtle changes in brain activity in the presence of both amyloid-beta and tau proteins may point to Alzheimer's disease, long before symptoms appear, a new study indicates.
Researchers used lab-grown brain cell models to show the virus can induce changes related to Alzheimer’s such as the production of amyloid and tau proteins linked to the death of nerve cells.
There are three main histological subtypes found at post-mortem: FTLD-tau, FTLD-TDP, and FTLD-FUS. In rare cases, patients with clinical FTD were found to have changes consistent with Alzheimer's disease on autopsy. [41] The most severe brain atrophy appears to be associated with behavioral variant FTD, and corticobasal degeneration. [42]
Moderate and severe traumatic brain injuries increase a risk of cognitive decline or dementia even years later by anywhere from two to four times, according to the Alzheimer’s Association. For ...
Alzheimer's disease is believed to occur when abnormal amounts of amyloid beta (Aβ), accumulating extracellularly as amyloid plaques and tau proteins, or intracellularly as neurofibrillary tangles, form in the brain, affecting neuronal functioning and connectivity, resulting in a progressive loss of brain function.
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