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A two-stage methodology was used; stage one defined a timeframe for futility using an online survey and steering group discussion; stage two applied this definition to patients enrolled in NELA December 2013–December 2020 for analysis. Futility was defined as all-cause mortality within 3 days of emergency laparotomy.
The design of many clinical trials includes some strategy for early stopping if an interim analysis reveals large differences between treatment groups, or shows obvious futility such that there is no chance that continuing to the end would show a clinically meaningful effect.
Futility is a novella written by Morgan Robertson, first published in 1898. It was revised as The Wreck of the Titan in 1912. It features a fictional British ocean liner named Titan that sinks in the North Atlantic Ocean after striking an iceberg .
"Futility" is a poem written by Wilfred Owen, one of the most renowned poets of World War I. The poem was written in May 1918 and published as no. 153 in The Complete Poems and Fragments . The poem is well known for its departure from Owen's famous style of including disturbing and graphic images in his work; the poem instead has a more ...
Futility or Futile may refer to: Futility, or the Wreck of the Titan, an 1898 novel "Futility" (poem), 1918 poem by Wilfred Owen; Futile, a 2003 EP album by Porcupine ...
In a pre-planned analysis, both trials met the pre-specified futility criteria for the primary endpoint of overall survival. ... This article Merck Discontinues Certain Cancer Candidate Trials ...
A two-stage methodology was used; stage one defined a timeframe for futility using an online survey and steering group discussion; stage two applied this definition to patients enrolled in NELA December 2013–December 2020 for analysis. Futility was defined as all-cause mortality within 3 days of emergency laparotomy.
Traditional futility interim is designed based on beta spending. However beta spending doesn't have an intuitive interpretation. Therefore it is difficult to communicate to non-statistician colleagues. Since PPOS has an intuitive interpretation, it makes more sense to design futility interim using PPOS.