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When a dog has wild-type alleles at all three genes, it will have a yellow coat. When the dog has a loss-of-function allele at MC1R, it will have a yellow coat regardless of the genes it carries on the other two genes. Only a dominant black allele at CBD103 will produce a black coat color in dogs possessing wild-type alleles at MC1R and Agouti. [8]
The ratio of primary to secondary hairs varies at least six-fold, and varies between dogs according to coat type, and on the same dog in accordance with seasonal and other hormonal influences. [61] Puppies are born with a single coat, with more hair follicles per unit area, but each hair follicle contains only a single hair of fine, silky texture.
Aeumelanic hair coats, associated with mutations of the MC1R gene, have also been identified in mice, [7] cattle, [8] dogs, [9] and horses. [10] These coat colors are called "yellow" in mice and dogs, "red" in cattle and chestnut in horses. The loss of eumelanin in the coat is, in these species, harmless.
A dog's coat is composed of two layers: a top coat of stiff guard hairs that help repel water and shield from dirt, and an undercoat of soft down hairs, to serve as insulation. [1] Dogs with both under coat and top coat are said to have a double coat. Dogs with a single coat have a coat composed solely of guard hairs, with little or no downy ...
An agouti dog, also called wolf sable. In dogs, the agouti gene is associated with various coat colors and patterns. [10]The alleles at the A locus are related to the production of agouti-signaling protein (ASIP) and determine whether an animal expresses an agouti appearance and, by controlling the distribution of pigment in individual hairs, what type of agouti.
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If a dog carries wild type alleles at all three loci, the dog will have a yellow coat. If a dog has a loss-of-function mutation at MC1R, it will also have a yellow coat, regardless of the genotypes at the other two loci. Dogs carrying wild-type alleles for MC1R and Agouti, together with the black allele of CBD103, will have a black coat. [17] [a]
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