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It can cause a black tongue and black stools in some users of the drug when it combines with trace amounts of sulfur in saliva and the colon to form bismuth sulfide. [7] Bismuth sulfide is a highly insoluble black salt, and the discoloration seen is temporary and harmless. Long-term use (more than six weeks) may lead to accumulation and ...
Bismuth(III) sulfide may be produced in the body by the reaction of the common gastrointestinal drug bismuth subsalicylate with naturally occurring sulfides; this causes temporary black tongue when the sulfides are in the mouth and black feces when the sulfides are in the colon.
Black hairy tongue syndrome (BHT [4]) is a condition of the tongue in which the small bumps on the tongue elongate with black or brown discoloration, giving a black and hairy appearance. The appearance may be alarming, but it is a harmless condition.
A case study recently published in the New England Journal of Medicine is raising awareness about a condition being referred to as 'black hairy tongue.'
Bismuth subsalicylate four times daily reduces rates of travelers' diarrhea. [2] [27] Though many travelers find a four-times-per-day regimen inconvenient, lower doses are not effective. [2] [27] Potential side effects include black tongue, black stools, nausea, constipation, and ringing in the ears.
The sixty-year-old patient’s face skin also turned grey, doctors say
Bismuth subsalicylate (BSS) has both antibacterial and anti-secretory actions that help with diarrhea. [1] Once in the gut, BSS gets broken down into bismuth and salicylic acid. [ 1 ] Bismuth produces other bismuth salts, which blocks the binding and proliferation of bacteria in stomach mucosal cells, leading to a decrease in inflammation in ...
Bismuth subsalicylate is an antimicrobial agent of another drug class that can also be used to eradicate H. pylori for treating PUD. Agents for suppressing gastric acid secretion are proton-pump inhibitors (PPI), such as lansoprazole , pantoprazole , rabeprazole , omeprazole and esomeprazole .
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