Ads
related to: nociceptin receptor
Search results
Results from the WOW.Com Content Network
The nociceptin opioid peptide receptor (NOP), also known as the nociceptin/orphanin FQ (N/OFQ) receptor or kappa-type 3 opioid receptor, is a protein that in humans is encoded by the OPRL1 (opioid receptor-like 1) gene. [5] The nociceptin receptor is a member of the opioid subfamily of G protein-coupled receptors whose natural ligand is the 17 ...
Nociceptin/orphanin FQ (N/OFQ), a 17-amino acid neuropeptide, is the endogenous ligand for the nociceptin receptor (NOP, ORL-1). Nociceptin acts as a potent anti-analgesic, effectively counteracting the effect of pain-relievers; its activation is associated with brain functions such as pain sensation and fear learning.
' pain receptor ') is a sensory neuron that responds to damaging or potentially damaging stimuli by sending "possible threat" signals [1] [2] [3] to the spinal cord and the brain. The brain creates the sensation of pain to direct attention to the body part, so the threat can be mitigated; this process is called nociception .
This receptor is known as the nociceptin receptor or ORL1 (opiate receptor-like 1). The opioid receptor types are nearly 70% identical, with the differences located at the N and C termini. The μ receptor is perhaps the most important. It is thought that the G protein binds to the third intracellular loop of all opioid receptors.
J-113,397 is an opioid drug which was the first compound found to be a highly selective antagonist for the nociceptin receptor, also known as the ORL-1 receptor. [1] [2] It is several hundred times selective for the ORL-1 receptor over other opioid receptors, [3] [4] and its effects in animals include preventing the development of tolerance to morphine, [5] the prevention of hyperalgesia ...
The pharmacology of R6890 is described as a nociceptin receptor (NOP) agonist, although R6890 retains significant activity at the mu opioid receptor. [5] R6890 has affinities (K i values) of 4, 75, and 10 nM for the mu, delta, and the total opioid receptor population, respectively.
Ro65-6570 is an opioid drug, it works by activating opioid receptors. However, instead of acting at the mu , kappa and delta receptors, it is instead an agonist at the nociceptin receptor . [ 4 ]
Ro64-6198 is an opioid drug used in scientific research. It acts as a potent and selective agonist for the nociceptin receptor, also known as the ORL-1 (opiate receptor like-1) receptor, with over 100x selectivity over the other opioid receptors. [1]
Ads
related to: nociceptin receptor