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S.M., sometimes referred to as SM-046, is an American woman with a peculiar type of brain damage that physiologically reduces her ability to feel fear.First described by scientists in 1994, [1] she has had exclusive and complete bilateral amygdala destruction since late childhood as a consequence of Urbach–Wiethe disease.
Urbach–Wiethe disease is inherited in an autosomal recessive manner. Urbach–Wiethe disease is a very rare recessive genetic disorder, with approximately 400 reported cases since its discovery. [1] [2] [3] It was first officially reported in 1929 by Erich Urbach and Camillo Wiethe, [4] [5] although cases may be recognized dating back as ...
There are cases of human patients with focal bilateral amygdala lesions due to the rare genetic condition Urbach-Wiethe disease. [86] [87] Such patients fail to exhibit fear-related behaviors, leading one, S.M., to be dubbed the "woman with no fear". This finding reinforces the conclusion that the amygdala "plays a pivotal role in triggering a ...
The other day a colleague sent me a text to cancel a meeting. “I’ve been so sick for the past several days,” she began. “I’ll need to reschedule.” I wasn’t sure whether she meant she ...
Klüver–Bucy syndrome is a syndrome resulting from lesions of the medial temporal lobe, particularly Brodmann area 38, [1] causing compulsive eating, hypersexuality, a compulsive need to insert inappropriate objects in the mouth (hyperorality), visual agnosia, and docility.
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Urbach-Wiethe disease (UWD) is a rare genetic disorder characterized by early damage to the basolateral amygdala. Perhaps more than 50% of the world's population of UWD live in South Africa, and together with his doctoral student, Helena Thornton , Stein initiated work on the neuropsychology of UWD.
One by one his platoon buddies were getting out of the Marines. Finally Joseph left too, and came home to Connecticut on Jan. 12, 2011. He left behind Frankie, his beloved pit bull mix; there was no place for him in Debbie’s two-floor duplex. A day or two later, Joseph called the VA to get help with his PTSD. He was told to send an email request.