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When investigating the selection of the polymer for biomedical applications, important criteria to consider are; The mechanical properties must match the application and remain sufficiently strong until the surrounding tissue has healed. The degradation time must match the time required. It does not invoke a toxic response.
There are vast examples and applications of biodegradable polymers. Bio-based packaging materials have been introduced as a green alternative in the past decades, among which, edible films have gained more attention due to their environmentally-friendly characteristics, vast variety and availability, non-toxicity, and low cost. [3]
An example of a compostable polymer is PLA film under 20μm thick: films which are thicker than that do not qualify as compostable, even though they are "biodegradable". [14] In Europe there is a home composting standard and associated logo that enables consumers to identify and dispose of packaging in their compost heap.
The biodegradable polymers used in biomedical applications typically consist of hydrolyzable esters and hydrazones. These molecules, upon external stimulation, go on to be cleaved and broken down. The cleaving activation process can be achieved through use of an acidic environment, increasing the temperature, or by use of enzymes. [82]
Bioplastics can be made from proteins from different sources. For example, wheat gluten and casein show promising properties as a raw material for different biodegradable polymers. [41] Additionally, soy protein is being considered as another source of bioplastic. Soy proteins have been used in plastic production for over one hundred years.
The application of biodegradable synthetic polymers began in the later 1960s. [38] Biodegradable materials have an advantage over other materials, as they have lower risk of harmful effects long term. In addition to ethical advancements using biodegradable materials, they also improve biocompatibility for materials used for implantation. [38]
Other biomedical applications include the use of biodegradable, elastic shape-memory polymers. Biodegradable implant materials can now be used for minimally invasive surgical procedures through degradable thermoplastic polymers. These polymers are now able to change their shape with increase of temperature, causing shape memory capabilities as ...
The most popular biofoam in the use of biomedical devices is PLA as well. PLA's properties are also desirable in biomedical applications, especially in combination with other polymers. [26] Specifically, its biocompatibility and biodegradability make it favorable in tissue engineering through the use of FDM-3D printing. [26]