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A more contemporary reporting standard includes the Grade Groups. [9] [10] [11] For prostate cancer, grade group information and prostate-specific antigen levels are used in conjunction with TNM status to group cases into four overall stages. [10] [citation needed] Grade Group 1 = Gleason 6 (or less) Grade Group 2 = Gleason 3+4=7; Grade Group 3 ...
For example, if the primary tumor grade was 2 and the secondary tumor grade was 3 but some cells were found to be grade 4, the Gleason score would be 2+4=6. This is a slight change from the pre-2005 Gleason system where the second number was the secondary grade (i.e., the grade of the second-most common cell line pattern).
8 to 10: “poorly differentiated” or “high-grade” Grades are assigned to two areas that comprise most of the cancer. The two grades are added together to come up with the Gleason score.
Those with localized tumors and PSA between 10 and 20 ng/mL are designated stage II – subdivided into IIA for Gleason grade group 1, IIB for grade group 2, and IIC for grade group 3 or 4. Stage III is the designation for any of three higher risk factors: IIIA is for a PSA level about 20 ng/mL; IIIB is for T3 or T4 tumors; IIIC is for a ...
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Achieving this grade requires centering between 65/35 to 70/30 on the front of the card, while the back should have centering of at least 90/10 or better. 9 - Mint - The card might exhibit only one of the subsequent flaws: a minor printing imperfection, borders that are slightly off-white, or an exceedingly faint wax stain on the back of the card.
2.8% [10] H&E and CK5/6 Carcinoma cells spanning entire lumen of ducts and acini [11] At least focal preservation of the basal cell layer [11] PSA+ [10] AMACR+ [10] Basal cell markers+ [10] Urothelial carcinoma 0.7 to 2.8% [12] Umbrella cells are usually present in low-grade tumors [13] Frequently branching fibrovascular cores [13] Frequently ...
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