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Micrograph showing hemosiderin-laden alveolar macrophages, as seen in a pulmonary hemorrhage. H&E stain.. An alveolar macrophage, pulmonary macrophage, (or dust cell) is a type of macrophage, a professional phagocyte, found in the airways and at the level of the alveoli in the lungs, but separated from their walls.
Macrophages are the predominant cells involved in creating the progressive plaque lesions of atherosclerosis. [89] Focal recruitment of macrophages occurs after the onset of acute myocardial infarction. These macrophages function to remove debris, apoptotic cells and to prepare for tissue regeneration. [90]
Cigarettes are known to cause many lung diseases including emphysema, chronic bronchitis, and lung cancer. Smoker's macrophages are alveolar macrophages whose characteristics, including appearance, cellularity, phenotypes, immune response, and other functions, have been affected upon the exposure to cigarettes. [1]
A pulmonary alveolus (pl. alveoli; from Latin alveolus ' little cavity '), also called an air sac or air space, is one of millions of hollow, distensible cup-shaped cavities in the lungs where pulmonary gas exchange takes place. [1] Oxygen is exchanged for carbon dioxide at the blood–air barrier between the alveolar air and the pulmonary ...
The major function of the lungs is gas exchange between the lungs and the blood. [67] The alveolar and pulmonary capillary gases equilibrate across the thin blood–air barrier . [ 34 ] [ 68 ] [ 69 ] This thin membrane (about 0.5 –2 μm thick) is folded into about 300 million alveoli, providing an extremely large surface area (estimates ...
Macrophages are diffusely scattered in the connective tissue and in liver (Kupffer cells), spleen and lymph nodes (sinus histiocytes), lungs (alveolar macrophages), and central nervous system (microglia). The half-life of blood monocytes is about 1 day, whereas the life span of tissue macrophages is several months or years.
A siderophage is a hemosiderin-containing macrophage. Heart failure cells are siderophages generated in the alveoli of the lungs of people with left heart failure or chronic pulmonary edema, when the high pulmonary blood pressure causes red blood cells to pass through the vascular wall. [1] Siderophages are not specific of heart failure.
18173 Ensembl ENSG00000018280 ENSMUSG00000026177 UniProt P49279 P41251 RefSeq (mRNA) NM_000578 NM_001032220 NM_013612 RefSeq (protein) NP_000569 NP_038640 Location (UCSC) Chr 2: 218.38 – 218.4 Mb Chr 1: 74.41 – 74.43 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Natural resistance-associated macrophage protein 1 is a protein that in humans is encoded by the SLC11A1 gene ...