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Full agonists bind to and activate a receptor with the maximum response that an agonist can elicit at the receptor. One example of a drug that can act as a full agonist is isoproterenol , which mimics the action of adrenaline at β adrenoreceptors .
5-MeO-NET, also known as 5-methoxy-N-ethyltryptamine, is a serotonin receptor agonist and serotonin releasing agent of the tryptamine family. [1] [2] [3] It is a potent full agonist or near-full agonist of the serotonin 5-HT 1A, 5-HT 2A, 5-HT 2B, and 5-HT 2C receptors. [1] [2] The drug is a relatively weak serotonin releasing agent. [2]
4-F-5-MeO-pyr-T, also known as 4-fluoro-5-methoxy-N,N-pyrrolidinyltryptamine, is a serotonin 5-HT 1A receptor agonist of the tryptamine family which was first synthesized and described by David E. Nichols and colleagues in 2001.
5-MeO-NiPT, also known as 5-methoxy-N-isopropyltryptamine, is a serotonin receptor agonist and serotonergic psychedelic of the tryptamine family. [1] [2] [3] It has been encountered as a novel designer and recreational drug. [2] [4] The drug is a full agonist or near-full agonist of the serotonin 5-HT 1A, 5-HT 2A, 5-HT 2B, and 5-HT 2C receptors.
Compared to salvinorin A, herkinorin has 47× lower affinity for κ-opioid receptors (K i ＝ 90 nM vs K i ＝ 1.9 nM), and at least 25× higher affinity for μ-opioid receptors (K i ＝ 12 nM vs K i >1000 nM), where it acts as a full agonist (IC 50 ＝ 0.5 μM, E max ＝ 130% vs DAMGO).
Functional selectivity has been proposed to broaden conventional definitions of pharmacology.. Traditional pharmacology posits that a ligand can be either classified as an agonist (full or partial), antagonist or more recently an inverse agonist through a specific receptor subtype, and that this characteristic will be consistent with all effector (second messenger) systems coupled to that ...
25B-NBOMe (NBOMe-2C-B, Cimbi-36, Nova, BOM 2-CB) is a derivative of the phenethylamine psychedelic 2C-B, discovered in 2004 by Ralf Heim at the Free University of Berlin.It acts as a potent full agonist for the 5HT 2A receptor.
An adamantyl-substituted derivative of Δ 8-THC, it is a potent and fairly selective CB 1 full agonist and a moderately potent CB 2 agonist. AM-630: 32.1: CB 2 (165×) 4.19: A potent and selective inverse agonist for the cannabinoid receptor CB 2 and a weak partial agonist at CB 1. AM-661: 1-(N-methyl-2-piperidine)methyl-2-methyl-3-(2-iodo ...