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Carbohydrase is the name of a set of enzymes that catalyze five types of reactions, turning carbohydrates into simple sugars, from the large family of glycosidases. [ 1 ] Carbohydrases are produced in the pancreas , salivary glands and small intestine , breaking down polysaccharides .
The drug is occasionally used on an intermittent basis to prevent seizures in catamenial epilepsy. [10] The sulfur-containing antiseizure and antimigraine drug topiramate is a weak inhibitor of carbonic anhydrase, particularly subtypes II and IV. [11] Whether carbonic anhydrase inhibition contributes to its clinical activity is not known.
Carbonic anhydrase was initially isolated and characterised from red blood cells in 1933, with simultaneous reports by Meldrum and Roughton (at Cambridge University in the United Kingdom) and by Stadie and O’Brien (at the University of Pennsylvania in the United States), [7] [8] both while searching for a "catalytic factor... necessary for rapid transit of the HCO 3 − [bicarbonate anion ...
Industrially the compound is produced by treatment of urea with hydrazine: [3] OC(NH 2) 2 + 2 N 2 H 4 → OC(N 2 H 3) 2 + 2 NH 3. It can also be prepared by reactions of other C1-precursors with hydrazine, such as carbonate esters. [2] It can be prepared from phosgene, but this route cogenerates the hydrazinium salt [N 2 H 5]Cl and results in ...
In pharmacology, the term mechanism of action (MOA) refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect. [2] A mechanism of action usually includes mention of the specific molecular targets to which the drug binds, such as an enzyme or receptor . [ 3 ]
Drug metabolism is the metabolic breakdown of drugs by living organisms, usually through specialized enzymatic systems. More generally, xenobiotic metabolism (from the Greek xenos "stranger" and biotic "related to living beings") is the set of metabolic pathways that modify the chemical structure of xenobiotics, which are compounds foreign to an organism's normal biochemistry, such as any drug ...
The Bills (11-3) are two games behind the 13-1 Kansas City Chiefs for the No. 1 seed in the AFC with three weeks to go, though Buffalo has the tiebreaker, thanks to its 30-21 win on Nov. 17.
Digestive enzymes are found throughout much of the gastrointestinal tract. In the human digestive system , the main sites of digestion are the mouth, stomach, and small intestine. Digestive enzymes are secreted by different exocrine glands including salivary glands , gastric glands , secretory cells in the pancreas , and secretory glands in the ...