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[9] [10] MIC values provide a quantitative measure of an extract or compound's antimicrobial potency. The lower the MIC, the more potent the antimicrobial. [4] When in vitro toxicity data is available, MICs can also be used to calculate selectivity index values, a measure of off-target to target toxicity. [4]
The minimum inhibitory concentration (MIC) and minimum bactericidal concentration are used to measure in vitro activity of antimicrobial agents. They are good indicators of antimicrobial potency, but don't give any information relating to time-dependent antimicrobial killing (the so-called post antibiotic effect). [1]
Etest and related instruments offer one of the most efficient methods for generating on-scale MIC values across 15 doubling dilutions for susceptibility testing of a wide range of drug-bug combinations, including fastidious organisms. Simplex C76 automates the placement of 1 to 6 different Etest strips to simplify the setup of MIC panels ...
Escherichia coli - 1 μg/mL - >512 μg/mL (this large range may be due to resistant organisms, typical MIC values are likely in the range of 2 -8 μg/mL. Klebsiella pneumoniae - 2 μg/mL - >256 μg/mL
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Surfactin is a cyclic lipopeptide, commonly used as an antibiotic for its capacity as a surfactant. [2] It is an amphiphile capable of withstanding hydrophilic and hydrophobic environments. The Gram-positive bacterial species Bacillus subtilis produces surfactin for its antibiotic effects against competitors. [ 3 ]
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