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Trazodone has a minor active metabolite known as meta-chlorophenylpiperazine (mCPP), and this metabolite may contribute to some degree to the pharmacological properties of trazodone. [ 11 ] [ 110 ] In contrast to trazodone, mCPP is an agonist of various serotonin receptors. [ 111 ]
Chemical structure of the serotonin antagonist and reuptake inhibitor trazodone.. Serotonin antagonist and reuptake inhibitors (SARIs) are a class of drugs used mainly as antidepressants, but also as anxiolytics and hypnotics.
This is a list of adverse effects of the antidepressant trazodone, ... [1] [2] [3] Very common. Very common (>10% incidence) adverse effects include: Blurred vision;
It is both a precursor in the synthesis of aripiprazole and one of its metabolites. [1] [2] It is unclear whether 2,3-DCPP is pharmacologically active as a serotonin receptor agonist similar to its close analogue 3-chlorophenylpiperazine (mCPP), though it has been shown to act as a partial agonist of the dopamine D 2 and D 3 receptors. [3]
Caution should be exercised in concomitant administration of CYP2D6 inhibitors such as bupropion, fluoxetine, paroxetine, and thioridazine with drugs that produce mCPP as a metabolite as these drugs are known to increase concentrations of the parent molecule (e.g., trazodone) and of mCPP. [51] [2]
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An atypical antidepressant is any antidepressant medication that acts in a manner that is different from that of most other antidepressants. Atypical antidepressants include agomelatine, bupropion, iprindole, mianserin, mirtazapine, nefazodone, opipramol, tianeptine, and trazodone.
One example is trazodone. [2] Other pharmaceutical drugs that contain a triazolopyridine ring system include filgotinib, tucatinib, and enarodustat. In addition, the reagents used in organic chemistry HATU, HOAt, and PyAOP [3] are triazolopyridine derivatives.