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Phage therapy is the use of bacteriophages to treat bacterial infections. Bacteriophage treatment offers a possible alternative to conventional antibiotic treatments for bacterial infection. [55] It is conceivable that, although bacteria can develop resistance to phages, the resistance might be easier to overcome than resistance to antibiotics.
Structural model at atomic resolution of bacteriophage T4 [1] The structure of a typical myovirus bacteriophage Anatomy and infection cycle of bacteriophage T4.. A bacteriophage (/ b æ k ˈ t ɪər i oʊ f eɪ dʒ /), also known informally as a phage (/ ˈ f eɪ dʒ /), is a virus that infects and replicates within bacteria and archaea.
Filamentous phages, unlike most other phages, are continually extruded through the bacterial membrane without killing the host. [19] Genetic studies on M13 using conditional lethal mutants, initiated by David Pratt and colleagues, led to description of phage gene functions.
Phage therapy is the method by which bacteriophages (viruses which infect bacteria) are used to treat bacterial infections or reduce bacterial populations. Phage therapy has gained recent attention in the United States as an alternative to standard antibiotic therapy .
Phages with a lysogenic life cycle are also called temperate phages. [2] Bacteriophage T12, proposed member of family Siphoviridae including related spe A-carrying bacteriophages, is also a prototypic phage for all the spe A-carrying phages of Streptococcus pyogenes , meaning that its genome is the prototype for the genomes of all such phages ...
Mycobacteriophage Bxb1 Structure [1]. A mycobacteriophage is a member of a group of bacteriophages known to have mycobacteria as host bacterial species. While originally isolated from the bacterial species Mycobacterium smegmatis and Mycobacterium tuberculosis, [2] the causative agent of tuberculosis, more than 4,200 mycobacteriophage species have since been isolated from various environmental ...
Ointments for the skin, and pills, drops, and rinses consisting of phages were sold and are still sold at pharmacies throughout Eastern Europe at low prices. [ 4 ] After the Republic of Georgia declined to join the Russian Federation and the Georgian Civil War broke out in 1991, the Tbilisi facility was essentially ruined.
Autographiviridae and other lytic phages lyse host bacteria through a process that begins with adsorption. [11] Once Autographiviridae is adsorbed on the cell surface of the host bacteria, the enzyme located in its tail structure can penetrate the host bacteria's peptidoglycan layer and inner membrane, where it releases genetic material into ...