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Cobalt is essential to the metabolism of all animals. It is a key constituent of cobalamin, also known as vitamin B 12, the primary biological reservoir of cobalt as an ultratrace element. [1] [2] Bacteria in the stomachs of ruminant animals convert cobalt salts into vitamin B 12, a compound which can only be produced by bacteria or archaea.
Vitamin B 12 is a coordination complex of cobalt, which occupies the center of a corrin ligand and is further bound to a benzimidazole ligand and adenosyl group. [18] Several related species are known and these behave similarly, in particular, all function as vitamins. This collection of compounds is sometimes referred to as "cobalamins".
Co 2+ - cobalt ions are present in the human body in amounts from 1 to 2 mg. [4] Cobalt is observed in the heart, liver, kidney, and spleen, and considerably smaller quantities in the pancreas, brain, and serum. [4] [5] Cobalt is a necessary component of vitamin B 12 and a fundamental coenzyme of cell mitosis. [5]
The five major minerals in the human body are calcium, phosphorus, potassium, sodium, and magnesium. [2] The remaining minerals are called "trace elements". The generally accepted trace elements are iron, chlorine, cobalt, copper, zinc, manganese, molybdenum, iodine, selenium, [5] and bromine; [6] there is some evidence that there may be more.
Parts-per-million cube of relative abundance by mass of elements in an average adult human body down to 1 ppm. About 99% of the mass of the human body is made up of six elements: oxygen, carbon, hydrogen, nitrogen, calcium, and phosphorus. Only about 0.85% is composed of another five elements: potassium, sulfur, sodium, chlorine, and magnesium ...
Metals have become so central to cellular function that the collection of metal-binding proteins (referred to as the metallomes) accounts for over 30% of all proteins in the cell. Metals are known to be involved in over 40% of enzymatic reactions, and metal-binding proteins carry out at least one step in almost all biological pathways .
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Trace metals within the human body include iron, lithium, zinc, copper, chromium, nickel, cobalt, vanadium, molybdenum, manganese and others. [1] [2] [3] Some of the trace metals are needed by living organisms to function properly and are depleted through the expenditure of energy by various metabolic processes of living organisms.