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MCF-7 is a breast cancer cell line isolated in 1970 from a 69-year-old White woman. [1] MCF-7 is the acronym of Michigan Cancer Foundation-7 , referring to the institute in Detroit where the cell line was established in 1973 by Herbert Soule and co-workers. [ 2 ]
The E-SCREEN cell proliferation assay is performed with the human MCF-7 breast cancer cell line, an established estrogenic cell line that endogenously expresses ERα. [ 1 ] [ 3 ] [ 4 ] Human MCF-7 are cultivated in Dulbecco’s modified Eagle’s medium (DMEM) with fetal bovine serum (FBS) and phenol red as buffer tracer (culture medium), at 37 ...
Cell line Primary tumor Origin of cells Estrogen receptors Progesterone receptors ERBB2 amplification Mutated TP53 [Notes 2] Tumorigenic in mice Reference External links 600MPE ...
T-47D cells can be implanted into immunodeficient mice, forming xenografts that can undergo drug testing with corresponding receptor status and angiogenesis changes. The cells have been noted to be extremely resistant to estrogens and antiestrogens, possibly due to inhibition by 5-bromodeoxyuridine and sodium butyrate.
SOURCE: Integrated Postsecondary Education Data System, Eastern Kentucky University (2014, 2013, 2012, 2011, 2010).Read our methodology here.. HuffPost and The Chronicle examined 201 public D-I schools from 2010-2014.
In 78 games, he averaged 10.8 points, 4.5 rebounds and 1.3 assists per game — good enough to see him finish third in rookie of the year voting and make the NBA All-Rookie First Team.
Rainn Wilson is doing some reflecting after losing a large portion of his home in a mountain fire.. The actor and podcast host, 58, first announced that he and wife Holiday Reinhorn’s California ...
E 2-3,4-Q can be converted back to 4-OHE 2 in a single step by quinone reductase, or in two sequential steps catalysed by P450 reductase via the semiquinone intermediate. GSH / S-transferase activity can abrogate E 2-3,4-Q levels via formation of glutathione conjugates. E 2-3,4-Q is a potent nucleophile, and will readily react with ...