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MCF-7 Cells. MCF-7 is a breast cancer cell line isolated in 1970 from a 69-year-old White woman. [1] MCF-7 is the acronym of Michigan Cancer Foundation-7, referring to the institute in Detroit where the cell line was established in 1973 by Herbert Soule and co-workers. [2]
Cell line Primary tumor Origin of cells Estrogen receptors Progesterone receptors ERBB2 amplification Mutated TP53 [Notes 2] Tumorigenic in mice Reference External links 600MPE ...
Originally the cell line was named MCF-7/ADR-RES; it was renamed together with the change in classification. [ 8 ] Two brain cancer cell lines, SNB-19 and U251 , were discovered to come from the same person. [ 9 ]
T-47D cells have been employed in studies of the effects of progesterone on breast cancer and the corresponding transcriptional regulation caused by introduced drugs. [3] T-47D cells can be implanted into immunodeficient mice, forming xenografts that can undergo drug testing with corresponding receptor status and angiogenesis changes.
The Bills' second-year tight end hasn't delivered the elite production fantasy owners who drafted him were hoping for in 2024. He has finished as a top-ten tight end twice in the first 10 games of ...
Between March 31 and Oct. 5 of this year, the percentage of cases grew from 1% to 7.2% among children ages 2 to 4, and from 3.6% to 7.4% among those ages 5 to 17, the agency stated.
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2) T-47D human breast cancer cells (which express very low levels of FFAR4) and MCF-7 cells transfected with the FFAR-1-producing plasmid had increased proliferative responses to oleic acid compared to control cells. [8] [65] 3) The highly selective FFAR4 agonist TUG-891 reduced the proliferation of MCF-7 and MDA-MB-231 cells.