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  2. Ketogenesis - Wikipedia

    en.wikipedia.org/wiki/Ketogenesis

    Ketogenesis pathway. The three ketone bodies (acetoacetate, acetone, and beta-hydroxy-butyrate) are marked within orange boxes. Ketogenesis is the biochemical process through which organisms produce ketone bodies by breaking down fatty acids and ketogenic amino acids.

  3. Ketone bodies - Wikipedia

    en.wikipedia.org/wiki/Ketone_bodies

    The concentration of ketone bodies in blood is maintained around 1 mg/dL. Their excretion in urine is very low and undetectable by routine urine tests (Rothera's test). [18] When the rate of synthesis of ketone bodies exceeds the rate of utilization, their concentration in blood increases; this is known as ketonemia.

  4. 3-Hydroxy-3-methylglutaryl-CoA lyase - Wikipedia

    en.wikipedia.org/wiki/3-hydroxy-3-methylglutaryl...

    n/a n/a Ensembl n/a n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) n/a n/a PubMed search n/a n/a Wikidata View/Edit Human Hydroxymethylglutaryl-CoA lyase HMG-CoA lyase dimer, Human Identifiers EC no. 4.1.3.4 CAS no. 9030-83-5 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB ...

  5. Hydroxymethylglutaryl-CoA synthase - Wikipedia

    en.wikipedia.org/wiki/Hydroxymethylglutaryl-CoA...

    The systematic name of this enzyme class is acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming).Other names in common use include (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase, (CoA-acetylating), 3-hydroxy-3-methylglutaryl CoA synthetase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthetase, 3 ...

  6. Ketogenic amino acid - Wikipedia

    en.wikipedia.org/wiki/Ketogenic_amino_acid

    A ketogenic amino acid is an amino acid that can be degraded directly into acetyl-CoA, which is the precursor of ketone bodies and myelin, particularly during early childhood, when the developing brain requires high rates of myelin synthesis. [1] This is in contrast to the glucogenic amino acids, which are converted into glucose.

  7. Acetoacetyl-CoA - Wikipedia

    en.wikipedia.org/wiki/Acetoacetyl-CoA

    This deficiency is classified as a disorder ketone body and isoleucine metabolism that can be inherited. [citation needed] Additional mutations include those with the enzymes within pathways related to Acetoacetyl CoA, including Beta-Ketothiolase deficiency and Mitochondrial 3-hydroxy-3-methylglutaryl-CoA Synthase mutation. Mevalonate pathway

  8. Acetyl-CoA - Wikipedia

    en.wikipedia.org/wiki/Acetyl-CoA

    It is produced during the breakdown of glucose, fatty acids, and amino acids, and is used in the synthesis of many other biomolecules, including cholesterol, fatty acids, and ketone bodies. Acetyl-CoA is also a key molecule in the citric acid cycle , which is a series of chemical reactions that occur in the mitochondria of cells and is ...

  9. BDH1 - Wikipedia

    en.wikipedia.org/wiki/BDH1

    The encoded protein forms a homotetrameric lipid-requiring enzyme of the mitochondrial membrane and has a specific requirement for phosphatidylcholine for optimal enzymatic activity. The encoded protein catalyzes the interconversion of acetoacetate and (R)-3-hydroxybutyrate, the two major ketone bodies produced during fatty acid catabolism.