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There is a connection between four parameters that characterize viruses during infection processes: replication rate (the rate at which viral RNA or DNA is synthesized intracellularly for viral progeny production), viral load (the total amount of virus quantified in an infected host or host compartment), genetic heterogeneity, and replicative ...
Name Description Knots [Note 1]Links References trRosettaRNA: trRosettaRNA is an algorithm for automated prediction of RNA 3D structure. It builds the RNA structure by Rosetta energy minimization, with deep learning restraints from a transformer network (RNAformer). trRosettaRNA has been validated in blind tests, including CASP15 and RNA-Puzzles, which suggests that the automated predictions ...
A computational model (2015) has shown that virus capsids may have originated in the RNA world and served as a means of horizontal transfer between replicator communities. These communities could not survive if the number of gene parasites increased, with certain genes being responsible for the formation of these structures and those that ...
In the 2002 metagenomics study the researchers found that 65% of the sequences of DNA and RNA viruses had no matches in the reference databases. [10] This phenomenon of unmatched viral sequences in sequence reference databases is prevalent in viral metagenomics studies and is referred to as “viral dark matter".
[2] [10] [11] Regardless of its plausibility in a prebiotic scenario, the RNA world can serve as a model system for studying the origin of life. [ 12 ] If the RNA world existed, it was probably followed by an age characterized by the evolution of ribonucleoproteins ( RNP world ), [ 3 ] which in turn ushered in the era of DNA and longer proteins.
Viral evolution is a subfield of evolutionary biology and virology concerned with the evolution of viruses. [1] [2] Viruses have short generation times, and many—in particular RNA viruses—have relatively high mutation rates (on the order of one point mutation or more per genome per round of replication).
The Kermack–McKendrick epidemic model (1927) and the Reed–Frost epidemic model (1928) both describe the relationship between susceptible, infected and immune individuals in a population. The Kermack–McKendrick epidemic model was successful in predicting the behavior of outbreaks very similar to that observed in many recorded epidemics. [7]
Taverna is an open source and domain-independent Workflow Management System – a suite of tools used to design and execute scientific workflows and aid in silico experimentation. TCW is a Transcriptome Computational Workbench. TRAPLINE a standardized and automated pipeline for RNA sequencing data analysis, evaluation and annotation.