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Hyaluronidase can be injected to dissolve hyaluronic acid type dermal fillers and is the best treatment option for those looking at dissolving lip filler or dealing with related complications. [ 13 ] Purified and recombinant hyaluronidases
[29] [30] Currently, hyaluronic acid is used as a soft tissue filler due to its bio-compatibility and possible reversibility using hyaluronidase. [31] [29] Complications include the severing of nerves and microvessels, pain, and bruising. Some side effects can also appear by way of erythema, itching, and vascular occlusion; vascular occlusion ...
This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma.
[23] [24] Enzymes such as hyaluronidase, [25] β-glucuronidase [26] of S. zooepidemicus decrease yield of HA. HA concentration is increased by deletion of associated genes of these enzymes. [25] [26] On the other hand, some enzymes induce HA production like sucrose-6-phosphatate hydrolase, [27] and hyaluronan synthase. [28]
Hyaluronidase PH-20 is an enzyme that in humans is encoded by the SPAM1 gene. [5] [6] [7] Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3.
Bovhyaluronidase azoximer, sold under the brand name Longidaze, is a conjugate of proteolytic enzyme hyaluronidase with high- molecular weight copolymer that forms a component of combination therapy regimens for treatment and prevention of diseases associated with connective tissue hyperplasia. [1]
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Hyaluronidase-2 is a multifunctional protein, previously thought to only possess acid-active hyaluronan-degrading enzymatic function. In humans it is encoded by the HYAL2 gene. [5] [6] [7] This gene encodes a protein which is similar in structure to hyaluronidases.
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