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The dynamic nature of loop extrusion is tightly controlled by accessory factors and post-translational modifications, especially in the case of cohesin. In vertebrates, NIPBL (and orthologs like Mau2 in yeast or SCC2 and SCC4) is crucial for loading SMC complexes onto DNA, initiating and maintaining active extrusion. PDS5 is thought to pause ...
Variable structure control (VSC) is a form of discontinuous nonlinear control. The method alters the dynamics of a nonlinear system by application of a high-frequency switching control . The state - feedback control law is not a continuous function of time; it switches from one smooth condition to another.
SMC's head office is located in Sotokanda, Chiyoda-ku, Tokyo, Japan. The company has a global engineering network, with technical facilities in the United States, Europe, and China, as well as Japan. Key production facilities are located in China and Singapore, and local production facilities are in United States, Mexico, Brazil, Europe, India ...
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In control systems, sliding mode control (SMC) is a nonlinear control method that alters the dynamics of a nonlinear system by applying a discontinuous control signal (or more rigorously, a set-valued control signal) that forces the system to "slide" along a cross-section of the system's normal behavior.
SMC dimers form a V-shaped molecule with two long coiled-coil arms. [19] [20] To make such a unique structure, an SMC protomer is self-folded through anti-parallel coiled-coil interactions, forming a rod-shaped molecule. At one end of the molecule, the N-terminal and C-terminal domains form an ATP-binding domain. The other end is called a hinge ...
Smc5 and Smc6 proteins form a heterodimeric ring-like structure and, together with other non-SMC elements, form the SMC-5/6 complex. In the worm Caenorhabditis elegans this complex interacts with the HIM-6(BLM) helicase to promote meiotic recombination intermediate processing and chromosome maturation. [ 20 ]