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Courtesy AIDS stigma—stigmatization of people connected to the issue of HIV/AIDS or HIV-positive people. [273] Often, AIDS stigma is expressed in conjunction with one or more other stigmas, particularly those associated with homosexuality, bisexuality, promiscuity, prostitution, and intravenous drug use. [274]
People with AIDS also have an increased risk of developing various cancers such as Kaposi's sarcoma, cervical cancer, and cancers of the immune system known as lymphomas. Additionally, people with AIDS often have systemic symptoms of infection like fevers, sweats (particularly at night), swollen glands, chills, weakness, and weight loss.
The AIDS epidemic, caused by HIV (Human Immunodeficiency Virus), found its way to the United States between the 1970s and 1980s, [2] but was first noticed after doctors discovered clusters of Kaposi's sarcoma and pneumocystis pneumonia in homosexual men in Los Angeles, New York City, and San Francisco in 1981.
The management of HIV/AIDS typically involves the use of multiple antiretroviral drugs. In many parts of the world, HIV has become a chronic condition, with progression to AIDS increasingly rare. HIV latency and the resulting viral reservoir in CD4 + T cells, dendritic cells, and macrophages is the main barrier to eradication of the virus.
At the beginning of the AIDS epidemic in the 1980s, there was very little information about the disease. Because AIDS disproportionately affected stigmatized groups, such as homosexuals, people of low socioeconomic status, sex workers and addicts, there was also initially little mass media coverage when the epidemic started. [107]
Tests selected to screen donor blood and tissue must provide a high degree of confidence that HIV will be detected if present (that is, a high sensitivity is required). A combination of antibody, antigen and nucleic acid tests are used by blood banks in Western countries.
Although AIDS is a global disease, the CDC reports that Sub-Saharan Africa has the highest prevalence of HIV and AIDS worldwide, and accounts for approximately 61% of all new HIV infections. Other regions significantly affected by HIV and AIDS include Asia and the Pacific, Latin America and the Caribbean, Eastern Europe, and Central Asia. [28]
The management of HIV/AIDS normally includes the use of multiple antiretroviral drugs as a strategy to control HIV infection. [1] There are several classes of antiretroviral agents that act on different stages of the HIV life-cycle. The use of multiple drugs that act on different viral targets is known as highly active antiretroviral therapy ...
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