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Available transdermal estradiol patches in the United States [1] [2] [a] Brand name Dose (µg/day) DOA (d) Size [b] [c] (cm 2) Levels (pg/mL) Intro. Alora [3] [4] 25, 50, 75, 100 3–4 9, 18, 27, 36 43–144 1996 Climara [d] [5] [6] 25, 37.5, 50, 60, 75, 100 7 6.5, 9.375, 12.5, 15, 18.75, 25 17–174 1994 Climara Pro [e] [7] [8] E2 (45)
Climara [c] Estrogen: TD patch: 25–400 μg/day Divigel [c] Estrogen: TD gel: 0.5–5 mg/day Various: Estrogen: SC implant: 50–200 mg every 6–24 mos Estradiol valerate: Progynova: Estrogen: Oral: 2–10 mg/day Progynova: Estrogen: Sublingual: 1–8 mg/day Delestrogen [c] Estrogen: IM, SC: 2–10 mg/wk or 5–20 mg every 2 wks Estradiol ...
Estradiol/levonorgestrel (E2/LNG), sold under brand name Climara Pro, is a combination of estradiol (E2) and levonorgestrel (LNG) which is used in menopausal hormone therapy. [ 1 ] [ 2 ] [ 3 ] It is a 22-cm 2 transdermal patch containing 4.4 mg estradiol and 1.39 mg levonorgestrel and delivers 45 μg/day estradiol and 15 μg/day levonorgestrel.
Estradiol: 150 μg/day: 300 μg/day: 600 μg/day Transdermal patch: Estradiol: 25 μg/day b: 50 μg/day b: 100 μg/day b: Transdermal gel: Estradiol: 0.5 mg/day: 1–1.5 mg/day: 2–3 mg/day Vaginal: Estradiol: 25 μg/day – – Estriol: 30 μg/day: 0.5 mg 2x/week: 0.5 mg/day IM Tooltip Intramuscular or SC injection: Estradiol valerate ...
Estradiol levels with 50 to 100 μg/day transdermal estradiol patches applied to the forearm and to the scrotum in a crossover study in 2 men with prostate cancer. [14] In 35 men treated continuously with one 100 μg/day estradiol patch scrotally, the mean estradiol level was ~500 pg/mL (range ~125–1,200 pg/mL).
This is a complete list of estrogens and formulations that are approved by the FDA Tooltip Food and Drug Administration and available in the United States. Estrogens are used as hormonal contraceptives , in hormone replacement therapy , and in the treatment of gynecological disorders .
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Transdermal estradiol gel did not become available in the United States until 2004, when EstroGel was introduced in this country as well. [223] A transdermal estradiol emulsion, Estrasorb, was marketed in the United States in 2003 as well. [223] One of the earliest reports of transdermal estradiol patches was published in 1983.
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