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Ultrasensitive Doppler has a typical 50-200 μm spatial resolution depending on the ultrasound frequency used. [2] It features temporal resolution ~10 ms, can image the full depth of the brain, and can provide 3D angiography. [10]
Photoacoustic imaging or optoacoustic imaging is a biomedical imaging modality based on the photoacoustic effect.Non-ionizing laser pulses are delivered into biological tissues and part of the energy will be absorbed and converted into heat, leading to transient thermoelastic expansion and thus wideband (i.e. MHz) ultrasonic emission.
Photoacoustic imaging combines the spatial resolution of ultrasound imaging with the contrast of optical absorption in deep biological tissue. [1] Ultrasound has good spatial resolution in deep biological tissue since ultrasonic scattering is much weaker than optical scattering, but it is insensitive to biochemical properties.
This particular biomedical imaging modality is a combination of optical imaging, and ultrasound imaging. In other words, a photoacoustic (PA) image can be viewed as an ultrasound image in which its contrast depends on the optical properties, such as optical resolution of biomolecules like hemoglobin, water, melanin, lipids, and collagen.
The theoretical model was first proposed by Yuan in 2009, he developed an ultrasound-modulated fluorescence based on a fluorophore-quencher-labeled microbubble system which can control the fluorescent emission inside the ultrasound-focal zone to increase the spatial resolution and SNR o f the imaging. [3]
By virtue of the linearity property of optical non-coherent imaging systems, i.e., . Image(Object 1 + Object 2) = Image(Object 1) + Image(Object 2). the image of an object in a microscope or telescope as a non-coherent imaging system can be computed by expressing the object-plane field as a weighted sum of 2D impulse functions, and then expressing the image plane field as a weighted sum of the ...
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Tip-enhanced Raman spectroscopy (TERS) is a variant of surface-enhanced Raman spectroscopy (SERS) [1] that combines scanning probe microscopy with Raman spectroscopy. High spatial resolution chemical imaging is possible via TERS, [2] with routine demonstrations of nanometer spatial resolution under ambient laboratory conditions, [3] or better [4] at ultralow temperatures and high pressure.