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Strontium ranelate, a strontium(II) salt of ranelic acid, is a medication for osteoporosis marketed as Protelos or Protos by Servier. Studies indicate it can also slow the course of osteoarthritis of the knee. [1] The drug is unusual in that it both increases deposition of new bone by osteoblasts and reduces the resorption of bone by ...
89 Sr is the active ingredient in Metastron, [76] a radiopharmaceutical used for bone pain secondary to metastatic bone cancer. The strontium is processed like calcium by the body, preferentially incorporating it into bone at sites of increased osteogenesis. This localization focuses the radiation exposure on the cancerous lesion. [24]
A bone seeker is an element, often a radioisotope, that tends to accumulate in the bones of humans and other animals when introduced into the body.. For example, strontium and radium are chemically similar to calcium and can replace the calcium in bones.
Strontium belongs to the same periodic family as calcium (alkaline earth metals), and is metabolised in a similar fashion, preferentially targeting metabolically active regions of the bone. 89 Sr is an artificial radioisotope used in the treatment of osseous (bony) metastases of bone cancer .
Vertex Pharmaceuticals claimed in a press release that the medication can be used for many types of moderate-to-severe acute pain and has shown no evidence that it is addictive, like opioids.
Naturally occurring strontium is nonradioactive and nontoxic at levels normally found in the environment, but 90 Sr is a radiation hazard. [4] 90 Sr undergoes β − decay with a half-life of 28.79 years and a decay energy of 0.546 MeV distributed to an electron, an antineutrino, and the yttrium isotope 90 Y, which in turn undergoes β − decay with a half-life of 64 hours and a decay energy ...
On the other hand, this also allows 89 Sr to be used in the open source radiotherapy of bone tumors. This tends to be used in palliative care to reduce the pain due to secondary tumors in the bones. Strontium-90 is a strong beta emitter with a half-life of 28.8 years.
An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]
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