Search results
Results from the WOW.Com Content Network
In analytical chemistry, the detection limit, lower limit of detection, also termed LOD for limit of detection or analytical sensitivity (not to be confused with statistical sensitivity), is the lowest quantity of a substance that can be distinguished from the absence of that substance (a blank value) with a stated confidence level (generally 99%).
A calibration curve plot showing limit of detection (LOD), limit of quantification (LOQ), dynamic range, and limit of linearity (LOL).. In analytical chemistry, a calibration curve, also known as a standard curve, is a general method for determining the concentration of a substance in an unknown sample by comparing the unknown to a set of standard samples of known concentration. [1]
Depending on the counting geometry of the system, count times can be from 1 minute to about 30 minutes. The sensitivity of a counter does depend on counting time so the longer the count, for the same system, the better the detection limit. The detection limit, often referred to as the Minimum Detectable Activity (MDA), is given by the formula:
There are different definitions within laboratory quality control, wherein "analytical sensitivity" is defined as the smallest amount of substance in a sample that can accurately be measured by an assay (synonymously to detection limit), and "analytical specificity" is defined as the ability of an assay to measure one particular organism or ...
log(Diagnostic Odds Ratio) for varying sensitivity and specificity. In medical testing with binary classification, the diagnostic odds ratio (DOR) is a measure of the effectiveness of a diagnostic test. [1]
For example, if the risk of developing health problems is known to increase with age, Bayes' theorem allows the risk to someone of a known age to be assessed more accurately by conditioning it relative to their age, rather than assuming that the person is typical of the population as a whole.
The control limits are set at three standard deviations on either side of the process mean, and are known as the upper control limit (UCL) and lower control limit (LCL) respectively. [2] If the process data plotted on the control chart remains within the control limits over an extended period, then the process is said to be stable. [2] [3]
The permissible exposure limit (PEL or OSHA PEL) is a legal limit in the United States for exposure of an employee to a chemical substance or physical agent such as high level noise. Permissible exposure limits were established by the Occupational Safety and Health Administration (OSHA).