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The therapeutic index (TI; also referred to as therapeutic ratio) is a quantitative measurement of the relative safety of a drug with regard to risk of overdose. It is a comparison of the amount of a therapeutic agent that causes toxicity to the amount that causes the therapeutic effect . [ 1 ]
Due to the narrow therapeutic index of flecainide, physicians should be alert for signs of toxicity before life-threatening arrhythmias occur like torsades de pointes. While the toxic effects of flecainide are closely related to the plasma levels of the drug, [ 19 ] it is unfeasible to check the plasma concentration in an individual on a ...
In addition, the therapeutic index of dextroproxyphene is relatively narrow. Caution should be used when administering dextropropoxyphene, particularly with children and the elderly and with patients who may be pregnant or breastfeeding; other reported problems include kidney, liver, or respiratory disorders, and prolonged use.
Tech stocks rallied in 2024, with powerhouse artificial intelligence (AI) stocks like Nvidia (NASDAQ: NVDA) and Palantir Technologies (NASDAQ: PLTR) bringing up the S&P 500 (SNPINDEX: ^GSPC). But ...
Another use is in the therapeutic drug monitoring of drugs with a narrow therapeutic index. For example, gentamicin is an antibiotic that can be nephrotoxic (kidney damaging) and ototoxic (hearing damaging); measurement of gentamicin through concentrations in a patient's plasma and calculation of the AUC is used to guide the dosage of this drug ...
SPY data by YCharts.. The table below shows how much you would need to have invested in a fund that mirrors the S&P 500 and might grow at a rate of 8% per year.
The S&P 500 (SNPINDEX: ^GSPC) is home to 500 companies from 11 different sectors of the economy, making it the most diversified of the major U.S. stock market indexes. The S&P 500 delivered a ...
The following table lists the largest biotechnology and pharmaceutical companies ranked by market capitalization in billion US dollars. The change column indicates the company's relative position in this list compared to their relative position in the preceding year; i.e., an increase would be moving closer to rank 1 and vice versa.