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  2. Lambda phage - Wikipedia

    en.wikipedia.org/wiki/Lambda_phage

    Lambda strains, mutated at specific sites, are unable to lysogenize cells; instead, they grow and enter the lytic cycle after superinfecting an already lysogenized cell. [ 3 ] The phage particle consists of a head (also known as a capsid ), [ 4 ] a tail, and tail fibers (see image of virus below).

  3. Sticky and blunt ends - Wikipedia

    en.wikipedia.org/wiki/Sticky_and_blunt_ends

    The simplest DNA end of a double stranded molecule is called a blunt end. Blunt ends are also known as non-cohesive ends. In a blunt-ended molecule, both strands terminate in a base pair. Blunt ends are not always desired in biotechnology since when using a DNA ligase to join two molecules into one, the yield is significantly lower with blunt ...

  4. Cosmid - Wikipedia

    en.wikipedia.org/wiki/Cosmid

    Those cells which did not take up the cosmid would be unable to grow. [3] Unlike plasmids, they can also be packaged in vitro into phage capsids, a step which requires cohesive ends, also known as cos sites also used in cloning with a lambda phage as a vector, however nearly all the lambda genes have been deleted with the exception of the cos ...

  5. Integration host factor - Wikipedia

    en.wikipedia.org/wiki/Integration_host_factor

    HU and integration host factor function as auxiliary proteins in cleavage of phage lambda cohesive ends by terminase is an academic journal written by the Department of Molecular Genetics. In their article, they created isogenic strains of E.coli that were lacking HU or integration host factors to test whether bacteriophage would grow under ...

  6. Ligation (molecular biology) - Wikipedia

    en.wikipedia.org/wiki/Ligation_(molecular_biology)

    Restriction enzymes can generate a wide variety of ends in the DNA they digest, but in cloning experiments most commonly-used restriction enzymes generate a 4-base single-stranded overhang called the sticky or cohesive end (exceptions include NdeI which generates a 2-base overhang, and those that generate blunt ends). These sticky ends can ...

  7. Cell adhesion - Wikipedia

    en.wikipedia.org/wiki/Cell_adhesion

    Schematic of cell adhesion. Cell adhesion is the process by which cells interact and attach to neighbouring cells through specialised molecules of the cell surface. This process can occur either through direct contact between cell surfaces such as cell junctions or indirect interaction, where cells attach to surrounding extracellular matrix, a gel-like structure containing molecules released ...

  8. Adapter (genetics) - Wikipedia

    en.wikipedia.org/wiki/Adapter_(Genetics)

    This adapter can be used to convert the cohesive end produced by Bam Hl to one produced by Eco Rl or vice versa. One of its applications is ligating cDNA into a plasmid [ 3 ] or other vectors instead of using Terminal deoxynucleotide Transferase enzyme to add poly A to the cDNA fragment.

  9. EcoRI - Wikipedia

    en.wikipedia.org/wiki/EcoRI

    EcoRI (pronounced "eco R one") is a restriction endonuclease enzyme isolated from species E. coli. It is a restriction enzyme that cleaves DNA double helices into fragments at specific sites, and is also a part of the restriction modification system. [1]