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Levels of p53 play an important role in the maintenance of stem cells throughout development and the rest of human life. [citation needed] In human embryonic stem cells (hESCs)s, p53 is maintained at low inactive levels. [31] This is because activation of p53 leads to rapid differentiation of hESCs. [32]
P53 diverged from p63/p73 with a gene duplication in the cartilaginous fish. [7] P63 and p73 differentiated from each other in bony fish. [ 7 ] In vertebrates, p53 began the role of protecting the somatic cells and acting as a tumor suppressor.
This suggests that p53 pathway could be effectively harnessed as a therapeutic intervention to trigger senescence and ultimately mitigate tumorigenesis. [4] p53 has been shown to have promising therapeutic relevance in an oncological context. In the 2007 Nature paper by Xue et al., RNAi was used to regulate endogenous p53 in a liver carcinoma ...
Metastatic HGSC arose in the ovaries of mouse triple knockouts of p53, PTEN and Dicer in which the Fallopian tubes had been removed, as well as in double murine knockouts of PTEN and p53 with intact Fallopian tubes. [20] The stem-cell-rich hilum region of the ovarian surface epithelium is a cancer-prone area. [23] Opposing:
Induced pluripotent stem cells are similar to natural pluripotent stem cells, such as embryonic stem cells, in many aspects, such as the expression of certain stem cell genes and proteins, chromatin methylation patterns, doubling time, embryoid body formation, teratoma formation, viable chimera formation, and potency and differentiability, but ...
In the field of genetics, a suicide gene is a gene that will cause a cell to kill itself through the process of apoptosis (programmed cell death). Activation of a suicide gene can cause death through a variety of pathways, but one important cellular "switch" to induce apoptosis is the p53 protein.
Stem Cell Research Showing New Possibilities For Treating Infant Heart Disease. He lives it every day, as he and his fellow researchers study and reprogram the potential of the blood to treat ...
The p53 upregulated modulator of apoptosis (PUMA) also known as Bcl-2-binding component 3 (BBC3), is a pro-apoptotic protein, member of the Bcl-2 protein family. [5] [6] In humans, the Bcl-2-binding component 3 protein is encoded by the BBC3 gene. [5] [6] The expression of PUMA is regulated by the tumor suppressor p53.
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