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Urea in low doses is a humectant while at high doses (above 20%) it causes breakdown of protein in the skin. [9] Urea dissolves the intercellular matrix of the cells of the stratum corneum, promoting desquamation of scaly skin, eventually resulting in softening of hyperkeratotic areas. [5]
The structure of the molecule of urea is O=C(−NH 2) 2.The urea molecule is planar when in a solid crystal because of sp 2 hybridization of the N orbitals. [8] [9] It is non-planar with C 2 symmetry when in the gas phase [10] or in aqueous solution, [9] with C–N–H and H–N–H bond angles that are intermediate between the trigonal planar angle of 120° and the tetrahedral angle of 109.5°.
Topical cream formulation is an emulsion semisolid dosage form that is used for skin external application. Most of the topical cream formulations contain more than 20 per cent of water and volatiles and/or less than 50 per cent of hydrocarbons , waxes , or polyethylene glycols as the vehicle for external skin application. [ 1 ]
The topical cream is indicated for treatment of facial hirsutism in women. [1] [18] It is the only topical prescription treatment that slows the growth of facial hair. [19] In clinical studies with Vaniqa, 81% percent of women showed clinical improvement after twelve months of treatment. [20] Positive results were seen after eight weeks. [21]
If you’re vegan or vegetarian and want to build muscle, you’ll need to aim to eat about 20 percent more total protein daily to ensure you’re getting all the essential amino acids, says ...
Many over-the-counter products contain either urea or propylene glycol. Moisturisers with lower-strength urea (10–20%) enhance the flexibility of the outer skin layer by acting as humectants. Propylene glycol, on the other hand, draws water through the outer skin layer, facilitating the shedding of thickened skin post-hydration.
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