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Albendazole is a broad-spectrum antihelmintic and antiprotozoal agent of the benzimidazole type. [3] It is used for the treatment of a variety of intestinal parasite infections, including ascariasis, pinworm infection, hookworm infection, trichuriasis, strongyloidiasis, taeniasis, clonorchiasis, opisthorchiasis, cutaneous larva migrans, giardiasis, and gnathostomiasis, among other diseases.
Anthelmintic effect of papain on Heligmosomoides bakeri. Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host.
ATC code P02 Anthelmintics is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
Treatment for hookworm infections depends on the species of hookworm and the species of the infected host. In humans, treatment is by anthelminthic medications, such as albendazole and mebendazole. [13] Treatment in animals can be done with a variety of anthelminthics. [1]
Those recommended by the World Health Organization for ascariasis are: albendazole, mebendazole, levamisole and pyrantel pamoate. [2] Single-dose of albendazole, mebendazole, and ivermectin are effective against ascariasis. They are effective at removing parasites and eggs from the intestines. [34]
In enzymology, an albendazole monooxygenase (EC 1.14.13.32) is an enzyme that catalyzes the chemical reaction. albendazole + NADPH + H + + O 2 albendazole S-oxide + NADP + + H 2 O. The four substrates of this enzyme are albendazole, NADPH, H +, and O 2, whereas its three products are albendazole S-oxide, NADP +, and H 2 O.
Albendazole was the first effective single dose nematocidal anthelminthic, one of the most widely used drugs in the developing world. [5] Both medicines were included in the World Health Organization's List of Essential Drugs. Rossignol would work with Davis for the next 10 years.
However, albendazole had a 95% cure rate for N. americanus, while mebendazole only had a 21% cure rate. This suggests albendazole is most effective for treating both T. trichiura and N. americanus. [7] During the 1910s, common treatments for hookworm included thymol, 2-naphthol, chloroform, gasoline, and eucalyptus oil. [8]
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