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Mycophenolate mofetil, a prodrug form of mycophenolic acid used in medicine. Mycophenolate mofetil is the morpholino ethyl ester of mycophenolic acid; the ester masks the carboxyl group. [42] Mycophenolate mofetil is reported to have a pKa values of 5.6 for the morpholino moiety and 8.5 for the phenolic group.
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Based on this, he tested the otherwise abandoned antibiotic, mycophenolate mofetil, as an inhibitor of the enzyme. After experimental success, with his wife, Elsie M. Eugui, he developed a safer derivative which was eventually approved as an immunosuppressive drug called CellCept. [3] He contributed more than 400 technical papers and edited 12 ...
Non-cytotoxic immunosuppressive treatments usually include the anti-rejection transplant drugs azathioprine (Imuran/Azoran) and mycophenolate mofetil (Cellcept). In the U.S., these drugs are used "off-label", meaning that they do not have an indication for the treatment of CIDP in their package inserts.
Simple English; Slovenščina ... Mycophenolate mofetil is used in combination with ciclosporin or tacrolimus in transplant patients. ... Wikipedia® is a registered ...
Bartolomeo Gosio (17 March 1863 – 13 April 1944) was an Italian medical scientist. [1] He discovered a toxic fume, eponymously named "Gosio gas", which is produced by microorganisms, that killed many people.
1,25 dihydroxycholecalciferol 1-Day 1-deamino-8-d-arginine vasopressin 13-cis-retinoic acid 2'-deoxycoformycin 2-amino-6-mercaptopurine 2-amino-6-trifluoromethoxy-benzothiazole 2-CdA 2-chlorodeoxyadenosine 2-PAM 2-propylpentanoic acid 2-propylvaleric acid 2-pyridine aldoxime methochloride 292 MEP 311C90 3M Avagard (Discontinued) 3M Cavilon Skin ...
mycophenolate mofetil (CellCept) Inhibits purine metabolism: Has partially replaced azathioprine due to proposed better efficacy and tolerability. Sometimes combined with steroids due to months-long onset of action. [1] corticosteroid [66] mitoxantrone: DNA synthesis/repair inhibitor: methotrexate: Inhibits folate metabolism: cyclophosphamide ...