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While rare, biotin deficiency can lead to symptoms such as thinning hair, skin rashes, brittle nails, fatigue and depression. ... However, too much biotin may cause false positives or false ...
Therefore, all patients receiving TPN must also receive biotin at the recommended daily dose, especially if TPN therapy is expected to last more than 1 week. All hospital pharmacies currently include biotin in TPN preparations. [2] Protein deficiency (not certain): A shortage of proteins involved in biotin homeostasis can cause biotin deficiency.
Vitamin K deficiency bleeding (VKDB) due to physiologically low vitamin K plasma concentrations is a serious risk for premature and term newborn and young infants. Untreated, consequences can cause brain damage or death. The prevalence of VKDB is reported at 0.25 to 1.7%, with higher risk in Asian populations.
Signs of a biotin deficiency may appear gradually, per the NIH. In the later stages, a biotin deficiency can cause: Hair thinning. Hair loss. A scaly, red rash around orifices. Dry, red eyes ...
Subclinical deficiency can cause mild symptoms, such as hair thinning, brittle fingernails, or skin rash, typically on the face. [2] [4] Aside from inadequate dietary intake (rare), deficiency of biotin can be caused by a genetic disorder that affects biotin metabolism. The most common among these is biotinidase deficiency.
Biotin deficiency is very uncommon, but experiencing it can cause an array of side effects, including: hair thinning or loss, brittle nails, a red scaly rash (around the eyes, nose, and mouth), a ...
Mutations in the BTD gene cause biotinidase deficiency. Biotinidase is the enzyme that is made by the BTD gene. Many mutations that cause the enzyme to be nonfunctional or to be produced at extremely low levels have been identified. Biotin is a vitamin that is chemically bound to proteins. (Most vitamins are only loosely associated with proteins.)
One important note: Excess biotin can also "cause incorrect results in certain laboratory tests that look at thyroid levels and blood markers that can help diagnose heart attacks," says Dr. Castillo.